ADH1B

Description		alcohol dehydrogenase 1B (class I), beta polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Ethanol oxidation
Drugs		NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974 28937693 23743675) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404) Alcohol consumption (drinks per week) ( 30643258 30679032 28485404 31959922) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 33290381 24166409 31090166 28714907 23456092 31591379 22004471) Alcohol dependence (desire to cut drinking) ( 31090166) Alcohol dependence (tolerance) ( 31090166) Alcohol dependence symptom count ( 31090166) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) Gout ( 33832965) Gout vs asymptomatic hyperuricemia ( 33832965) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Maximum habitual alcohol consumption ( 31151762) Metabolite levels ( 23823483) Oral cavity and pharyngeal cancer ( 27749845 21437268) Oral cavity cancer ( 27749845) Oropharynx cancer ( 27749845) Problematic alcohol use ( 32451486) Regular attendance at a pub or social club ( 29970889) Relative fat intake ( 32393786) Relative protein intake ( 32393786) Reticulocyte count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Urinary sodium excretion ( 31409800)
Interacting Genes		5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3
Entrez ID		125
HPRD ID		00065
Ensembl ID		ENSG00000196616
Uniprot IDs		D6RHZ6 P00325 V9HW50
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?		Molecular Adaptor Activity Response To Peptide Response To Cytokine Negative Regulation Of Translation In Response To Oxidative Stress Protein Homodimerization Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Component Organization Cortical Microtubule Plus-end IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Positive Regulation Of Macrophage Tolerance Induction Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cobalt Ion Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Localization To Chromosome, Telomeric Region Ubiquitin-like Protein Ligase Activity Negative Regulation Of Translation Regulation Of Cellular Component Organization Negative Regulation Of Translational Initiation In Response To Stress Oncogene-induced Cell Senescence Negative Regulation Of Growth Positive Regulation Of Apoptotic Process Involved In Morphogenesis PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Translational Elongation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Gastrulation Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding Toll Signaling Pathway Rhythmic Process Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Microtubule Nucleation Protein Tyrosine Kinase Inhibitor Activity Positive Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Translation In Response To Stress Positive Regulation Of Mitochondrial Depolarization Regulation Of Translational Initiation In Response To Stress SUMO Binding Astral Microtubule Organization Regulation Of Translational Elongation Regulation Of Golgi To Plasma Membrane Protein Transport Homeostatic Process Protein Heterodimerization Activity Negative Regulation Of Cytokine Production Positive Regulation Of Membrane Depolarization
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