ADH1B and PDE4DIP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH1B	PDE4DIP
Gene Name		alcohol dehydrogenase 1B (class I), beta polypeptide	phosphodiesterase 4D interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding	Protein Binding Enzyme Binding
	Biological Process	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process	Cellular Protein Complex Assembly
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs		NADH Ethanol Fomepizole Nicotinamide-Adenine-Dinucleotide N-Benzylformamide 4-Iodopyrazole 2\'-Monophosphoadenosine 5\'-Diphosphoribose Cyclohexanol Glycerol N-Heptylformamide
Diseases
GWAS		Alcohol consumption ( 23743675) Alcohol dependence ( 23456092 22004471) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) Upper aerodigestive tract cancers ( 21437268)	Capecitabine sensitivity ( 22864933)
Protein-Protein Interactions		5 interactors: GNB2L1 IRAK3 PDE4DIP PML SERPINA3	64 interactors: ADH1B AEN ANKRD11 ARNT2 BYSL C14orf105 C19orf66 C1orf109 CCDC146 CDC5L CDKN1A CHCHD3 FAM161A FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 IMMT ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LMO4 MAPRE1 MIF4GD MTUS2 NAA10 NEFL NEK2 OSGEP PDE4D PFDN1 PIAS4 PPP1R18 PRNP PRPF31 RTP5 SCNM1 SDCBP SH2D4A SMN1 SNCA TFIP11 TK1 TNIK TRAF4 UTP14C VAC14 ZBTB38 ZFYVE21 ZNF408 ZNF512B ZNF581 ZSCAN26
Entrez ID		125	9659
HPRD ID		00065	10482
Ensembl ID			ENSG00000178104
Uniprot IDs		A8MYN5 P00325	F8WAP3 Q5VU43
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Peptidase Activity Negative Regulation Of Translation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Translation In Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Positive Regulation Of CAMP Catabolic Process Negative Regulation Of Cell Growth Regulation Of Ion Homeostasis Regulation Of Catalytic Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity PML Body Organization Protein Processing Negative Regulation Of Growth Negative Regulation Of Telomere Maintenance Via Telomerase Response To Virus Regulation Of Translation Negative Regulation Of Oxidative Stress-induced Neuron Death Common-partner SMAD Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Phosphorylation Rhythmic Process SMAD Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Translation In Response To Stress Negative Regulation Of Protein Phosphorylation	Developmental Process Response To Copper Ion RNA Metabolic Process Anatomical Structure Development Nucleobase-containing Compound Metabolic Process Regulation Of Microtubule Polymerization Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Copper Ion Response To Mineralocorticoid Cellular Nitrogen Compound Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Regulation Of Phosphorylation Response To Glucocorticoid Regulation Of JNK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Nitrogen Compound Metabolic Process Response To Corticosteroid Regulation Of Metabolic Process Regulation Of Microtubule-based Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Epinephrine Stimulus Regulation Of Cellular Component Organization System Development Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Response To Epinephrine RNA Splicing Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Histone H3-K4 Methylation Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant
Tagcloud (Difference) ?		acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant
Tagcloud (Intersection) ?