CCDC43 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CCDC43	KLHL2
Description		coiled-coil domain containing 43	kelch like family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Protein Binding	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process		Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		4 interacting genes: KLHL2 LRRK2 MFHAS1 TINF2	29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		124808	11275
HPRD ID		08107	09311
Ensembl ID		ENSG00000180329	ENSG00000109466
Uniprot IDs		Q96MW1	B4DFZ5 E9PEX9 O95198
PDB IDs			2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Regulation Of Macrophage Activation Perinucleolar Chromocenter Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Protein Autoubiquitination Response To Curcumin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Shelterin Complex Telomere Assembly Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Multivesicular Body, Internal Vesicle Regulation Of Kidney Size Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Nuclear Telomere Cap Complex JUN Kinase Kinase Kinase Activity Positive Regulation Of Microglial Cell Activation Regulation Of Neuron Maturation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Localization To Endoplasmic Reticulum Exit Site Cellular Response To Manganese Ion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Response To Dopamine GTP Binding Cytoskeleton Actin Binding Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of Autophagosome Assembly Regulation Of ER To Golgi Vesicle-mediated Transport Co-receptor Binding Regulation Of Dopamine Receptor Signaling Pathway	Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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