RALYL and MBD2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		RALYL	MBD2
Description		RALY RNA binding protein like	methyl-CpG binding domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol NuRD Complex Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding	DNA Binding Chromatin Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding Identical Protein Binding Molecular Adaptor Activity C2H2 Zinc Finger Domain Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Response To Mechanical Stimulus Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Population Proliferation Maternal Behavior Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Protein-containing Complex Assembly Response To Bisphenol A Cellular Response To Serotonin
Pathways			NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systolic blood pressure ( 27841878) Trunk fat mass ( 28552196)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		25 interacting genes: ADISSP AEBP2 AEN BYSL CAMK2A CCDC85B CEP170P1 EWSR1 EXOSC7 FXR1 FXR2 HNRNPC LMO3 LRRK2 MBD2 MCRS1 NXF1 PCBP2 PSMF1 RBM41 THAP1 TIGD3 TSC1 TSNAX ZNF408	21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP
Entrez ID		138046	8932
HPRD ID		11236	04647
Ensembl ID		ENSG00000184672	ENSG00000134046
Uniprot IDs		B3KT61 Q86SE5	Q9UBB5
PDB IDs			2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA 7MWK 7MWM 7RAY
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus RNA Binding MRNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleolus Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Translation Regulator Activity Cytoplasmic Stress Granule Nucleoplasm Regulation Of RNA Metabolic Process Protein Homodimerization Activity Poly(U) RNA Binding Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening MRNA 3'-UTR AU-rich Region Binding MRNA Transport Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Hydrolase Activity Peptidyl-threonine Autophosphorylation Neuron Projection Negative Regulation Of Telomere Maintenance Memory T Cell Differentiation Negative Regulation Of Macroautophagy RNA Transport Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleosomal DNA Binding Presynaptic Modulation Of Chemical Synaptic Transmission Nucleolus Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of MRNA Stability U12 SnRNA Binding	NuRD Complex Regulation Of Cell Fate Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Fate Commitment Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleosomal DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Methyl-CpG Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Nucleus Constitutive Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Biosynthetic Process Protein-containing Complex Regulation Of Stem Cell Population Maintenance DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein Lysine Delactylase Activity Fungiform Papilla Formation
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