NUP62 and CENPU

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NUP62	CENPU
Description		nucleoporin 62	centromere protein U
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Cytoskeleton Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Centriolar Satellite
	Molecular Function	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding PTB Domain Binding Hsp90 Protein Binding	Protein Binding
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Mitotic Metaphase Chromosome Alignment Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Cellular Senescence Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome	Chromosome Segregation Chordate Embryonic Development
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Interacting Genes		88 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DRC12 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 IDH1 IFT20 IFT25 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NUP153 NUP54 NUP58 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6	20 interacting genes: CENPQ E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 OGT PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		23636	79682
HPRD ID		05782	14722
Ensembl ID		ENSG00000213024	ENSG00000151725
Uniprot IDs		P37198	Q71F23
PDB IDs		5IJN 5IJO 7PER 7R5J 7R5K	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH 8K4D
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Nuclear Pore NLS-bearing Protein Import Into Nucleus RNA Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Export MRNA Transport Intracellular Transport Nuclear Import Signal Receptor Activity Protein Localization To Nucleus Protein Transport Establishment Of Protein Localization Structural Constituent Of Nuclear Pore Intermediate Filament Organization Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Inclusion Body Protein Binding Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intracellular Protein Transport Cellular Localization Protein Localization To Organelle Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle Supramolecular Fiber Organization Nuclear Envelope Intracellular Protein Localization Intracellular Transport Of Virus Keratin Filament Host Cell NLS-dependent Protein Nuclear Import Complex Cytoskeleton Organization Small GTPase Binding Intermediate Filament Protein Export From Nucleus Keratinization Nuclear Pore Nuclear Basket Regulation Of Nucleocytoplasmic Transport Nuclear Pore Organization Identical Protein Binding RNA Export From Nucleus Nucleus Organization Organelle Organization Ribosomal Protein Import Into Nucleus Viral Penetration Into Host Nucleus	Regulation Of Cellular Component Organization Spindle Pole Regulation Of Cytokinesis Positive Regulation Of Protein Localization Regulation Of Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Division Regulation Of Protein Localization Centrosome Separation Regulation Of Protein-containing Complex Assembly Cytoskeleton Regulation Of Cell Cycle Negative Regulation Of Cellular Component Organization Negative Regulation Of Synapse Organization Cell Junction Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Organization Synapse Organization Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Synapse Organization Regulation Of Centriole Replication Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Organization Regulation Of Protein Catabolic Process Centrosome Cell Cycle Phase Transition Kinetochore Regulation Of Synapse Assembly Negative Regulation Of Catabolic Process Positive Regulation Of Translation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Pole Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Metabolic Process Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
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