NUP62 and FABP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		NUP62	FABP3
Description		nucleoporin 62	fatty acid binding protein 3
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Cytoskeleton Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex	Extracellular Space Nucleus Cytoplasm Cytosol Sarcoplasm Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding PTB Domain Binding Hsp90 Protein Binding	Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Binding Protein Binding Cytoskeletal Protein Binding Lipid Binding Long-chain Fatty Acid Binding Icosatetraenoic Acid Binding Oleic Acid Binding
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Mitotic Metaphase Chromosome Alignment Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Cellular Senescence Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome	Fatty Acid Metabolic Process Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Long-chain Fatty Acid Transport Intracellular Lipid Transport Response To Insulin Cholesterol Homeostasis Regulation Of Fatty Acid Oxidation Brown Fat Cell Differentiation Phospholipid Homeostasis Response To Fatty Acid Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Long-chain Fatty Acid Import Into Cell Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Triglyceride catabolism
Drugs
Diseases
GWAS			Alcohol dependence ( 23455491) Body mass index ( 26426971) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		88 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DRC12 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 IDH1 IFT20 IFT25 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NUP153 NUP54 NUP58 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6	4 interacting genes: NUP62 SHTN1 TNNI3K VPS28
Entrez ID		23636	2170
HPRD ID		05782	00613
Ensembl ID		ENSG00000213024	ENSG00000121769
Uniprot IDs		P37198	A0A384MDY5 P05413
PDB IDs		5IJN 5IJO 7PER 7R5J 7R5K	1G5W 1HMR 1HMS 1HMT 2HMB 3RSW 3WBG 3WVM 3WXQ 4TJZ 4TKB 4TKH 4TKJ 4WBK 5B27 5B28 5B29 5CE4 5HZ9 6AQ1 7EGO 7EUV 7EUW 7FBF 7FBM 7FBN 7FC4 7FCG 7FCX 7FD7 7FDT 7FDU 7FDX 7FEK 7FEU 7FEZ 7FF6 7FFK 7FFX 7FG1 7FG5 7FZQ 7V2G 7V5U 7VB1 7WCI 7WD6 7WDJ 7WE5 7WF0 7WJ1 7WKB 7WKG 7WOM 7WPG 7WPU 7WPW 7WQ7 7X48 7X4J 7X50 7XBC 7XHM 7XHU 8GEW
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Nuclear Pore NLS-bearing Protein Import Into Nucleus RNA Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Export MRNA Transport Intracellular Transport Nuclear Import Signal Receptor Activity Protein Localization To Nucleus Protein Transport Establishment Of Protein Localization Structural Constituent Of Nuclear Pore Intermediate Filament Organization Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Inclusion Body Protein Binding Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intracellular Protein Transport Cellular Localization Protein Localization To Organelle Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle Supramolecular Fiber Organization Nuclear Envelope Intracellular Protein Localization Intracellular Transport Of Virus Keratin Filament Host Cell NLS-dependent Protein Nuclear Import Complex Cytoskeleton Organization Small GTPase Binding Intermediate Filament Protein Export From Nucleus Keratinization Nuclear Pore Nuclear Basket Regulation Of Nucleocytoplasmic Transport Nuclear Pore Organization Identical Protein Binding RNA Export From Nucleus Nucleus Organization Organelle Organization Ribosomal Protein Import Into Nucleus Viral Penetration Into Host Nucleus	Ubiquitin Binding Endoplasmic Reticulum Polarization Actin Filament Bundle Retrograde Transport PTB Domain Binding Bundle Of His Cell To Purkinje Myocyte Communication Positive Regulation Of Ubiquitin-dependent Endocytosis Cdc42 Protein Signal Transduction Positive Regulation Of Cellular Component Organization Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Peptidyl-serine Autophosphorylation Cytoplasmic Actin-based Contraction Involved In Cell Motility Netrin-activated Signaling Pathway Establishment Of Protein Localization To Organelle Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Centriole Replication ESCRT I Complex Centrosome Separation Regulation Of Protein Localization To Centrosome Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Positive Regulation Of Neuron Migration Positive Regulation Of Protein Localization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
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