PIK3AP1 and ITSN1

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		PIK3AP1	ITSN1
Gene Name		phosphoinositide-3-kinase adaptor protein 1	intersectin 1 (SH3 domain protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Inflammatory Response	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: BTK GRB2 ITSN1 ITSN2 PIK3R1 SYK	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		118788	6453
HPRD ID		06401	03898
Ensembl ID		ENSG00000155629	ENSG00000205726
Uniprot IDs		Q6ZUJ8 Q86YV3	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs			1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Fungal Origin Vesicle-mediated Transport Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Molecule Of Fungal Origin Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Immune Response Cell Activation Platelet Activation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Intracellular Signal Transduction Production Of Molecular Mediator Involved In Inflammatory Response Innate Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of B Cell Differentiation Regulation Of Immune Response Phagocytosis Positive Regulation Of Immune System Process Regulation Of T Cell Activation Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Response To Fungus Apoptotic Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Response To Organic Substance Transport Lymphocyte Activation Blood Coagulation Locomotion Hemostasis	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?		450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 pax5 plcb1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 plcb1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?		pax5