PIK3AP1

Description		phosphoinositide-3-kinase adaptor protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding
	Biological Process	Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Orthostatic hypotension ( 24124408) Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		8 interacting genes: BTK GRB2 ITSN1 ITSN2 NCK1 NCK2 PIK3R1 SYK
Entrez ID		118788
HPRD ID		06401
Ensembl ID		ENSG00000155629
Uniprot IDs		Q6ZUJ8
PDB IDs		5FOR 6SWS
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Lymphocyte Activation Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Leukocyte Activation Positive Regulation Of Cellular Component Organization Cell Activation T Cell Activation Regulation Of Cellular Component Organization Positive Regulation Of Lymphocyte Activation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Protein-containing Complex Assembly Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Receptor-mediated Endocytosis Positive Regulation Of Immune System Process Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Actin Filament Polymerization Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process B Cell Receptor Signaling Pathway Protein-macromolecule Adaptor Activity Response To Molecule Of Fungal Origin Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Mononuclear Cell Proliferation Innate Immune Response Regulation Of Cell Activation Regulation Of Actin Filament Organization Positive Regulation Of T Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Translation In Response To Stress Regulation Of Leukocyte Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Complex Assembly Positive Regulation Of Protein Polymerization Defense Response To Symbiont Defense Response To Other Organism Regulation Of Translation In Response To Endoplasmic Reticulum Stress
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