SPTB and ANK1

Number of citations: 0 (PubMedID 2141335)
Data Source: BioGRID (pull down)

		SPTB	ANK1
Name		spectrin beta, erythrocytic	ankyrin 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Protein-containing Complex Cell Projection Synapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band A Band Sarcolemma Neuron Projection Postsynaptic Membrane Cell Periphery Ankyrin-1 Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Transmembrane Transporter Binding ATPase Binding
	Biological Process	Actin Cytoskeleton Organization Synapse Organization Actin Filament Capping Modification Of Postsynaptic Actin Cytoskeleton	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Golgi Vesicle Transport Protein Localization To Plasma Membrane
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Diseases		Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)	Hereditary spherocytosis (SPH)
GWAS		Daytime sleep phenotypes ( 27126917 ) Glycated hemoglobin levels ( 34059833 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Pediatric areal bone mineral density (radius) ( 28181694 ) Red cell distribution width ( 28957414 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Type 2 diabetes ( 31049640 )	Apolipoprotein B levels ( 32203549 ) Birth weight ( 31043758 27680694 ) Corrected insulin response ( 24699409 ) Corrected insulin response adjusted for insulin sensitivity index ( 24699409 ) Glycated hemoglobin levels ( 20858683 34059833 31213470 24647736 28898252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Insulin levels adjusted for BMI ( 24699409 ) LDL cholesterol levels ( 32203549 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 28017375 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Pulmonary function decline ( 22424883 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Sleep duration ( 30531941 ) Type 2 diabetes ( 22456796 32499647 22885922 24509480 26818947 28869590 29358691 30054458 30297969 30718926 )
Novel Interactors		1 novel interactors: RBPJ	1 novel interactors: CBR3
Interacting Genes		18 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 NRIP1 SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ	28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN
Entrez ID		6710	286
HPRD ID		01686	01693
Ensembl ID		ENSG00000070182	ENSG00000029534
Uniprot IDs		P11277	B3KX39 P16157
PDB IDs		1S35 3EDU 3F57 3KBT 3KBU 3LBX	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2 7TW3 7TW5 7TW6 7UZQ 7UZU 7V0K 7V0M 7V0S 7V0X 8CS9 8CSL 8CSV 8CTE
GO Terms Enriched among Interactors		Spectrin-associated Cytoskeleton Cortical Cytoskeleton Spectrin Binding Actin Filament Capping Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Cytosol Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cytoskeleton Organization Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Cellular Component Size Cytoskeleton Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Organelle Organization Cytoplasm Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Spectrin Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament Binding Cell Junction Negative Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Axolemma Supramolecular Fiber Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Mesenchymal Cell Differentiation Regulation Of Cytoskeleton Organization Cytoskeletal Anchor Activity Protein Phosphatase 2A Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Localization To Cell Periphery Kinesin Binding Axon Substantia Nigra Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Melanosome Organization Pigment Granule Organization	Ankyrin Binding Ankyrin-1 Complex Spectrin Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Z Disc Chemical Homeostasis Bicarbonate Transport Plasma Membrane M Band Cortical Cytoskeleton Structural Constituent Of Cytoskeleton Intracellular Chemical Homeostasis Actin Filament Binding Actin Filament Capping Homeostatic Process Negative Regulation Of Actin Filament Depolymerization Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Cellular Homeostasis Bicarbonate Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Membrane Intracellularly Gated Calcium Channel Activity Monoatomic Anion Transmembrane Transporter Activity Cortical Actin Cytoskeleton Inorganic Ion Transmembrane Transport Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Sarcoplasmic Reticulum Cell Cortex Negative Regulation Of Protein-containing Complex Disassembly Actin Cytoskeleton Organization Calmodulin Binding Transmembrane Transport Regulation Of Protein Depolymerization Intracellular Monoatomic Cation Homeostasis Actin Filament-based Process Antiporter Activity Secretory Granule Membrane Chloride Transmembrane Transport Focal Adhesion Cell-matrix Adhesion Chloride Transport Cytoplasmic Side Of Plasma Membrane Multicellular Organismal-level Iron Ion Homeostasis I Band Cell-cell Contact Zone