SPTB and SPTA1

Number of citations of the paper that reports this interaction (PMID 1634521)
21

Data Source:
HPRD (in vitro)

		SPTB	SPTA1
Gene Name		spectrin, beta, erythrocytic	spectrin, alpha, erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Spectrin Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein Complex	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Protein Heterodimerization Activity Actin Filament Binding	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Axon Guidance Hemopoiesis Actin Filament Capping	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Glycated hemoglobin levels ( 20858683) Other erythrocyte phenotypes ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		11 interactors: ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SPTA1 SPTAN1 YWHAQ	16 interactors: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 UBC VASP YWHAQ
Entrez ID		6710	6708
HPRD ID		01686	01685
Ensembl ID		ENSG00000070182	ENSG00000163554
Uniprot IDs		P11277 Q59FP5 Q86TX9	P02549
PDB IDs		1S35 3EDU 3F57 3KBT 3KBU 3LBX	1OWA 3LBX
Enriched GO Terms of Interacting Partners?		Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Protein Complex Disassembly Negative Regulation Of Protein Complex Assembly Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Cell Differentiation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Axonogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Morphogenesis Axon Development Homeostasis Of Number Of Cells Positive Regulation Of Protein Binding Cell Morphogenesis Involved In Neuron Differentiation Cell Development Developmental Process Actin Cytoskeleton Organization Execution Phase Of Apoptosis Neuron Projection Morphogenesis Actin Filament-based Process Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Differentiation Organelle Organization Erythrocyte Differentiation Regulation Of Actin Cytoskeleton Organization Erythrocyte Homeostasis Neuron Projection Development Multicellular Organismal Development Positive Regulation Of Binding Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Anatomical Structure Development Anatomical Structure Morphogenesis Myeloid Cell Homeostasis Regulation Of Protein Binding	Actin Filament Organization Cell Development Axon Guidance Cell Morphogenesis Immune System Process Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament-based Process Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Cell Projection Organization Actin Polymerization Or Depolymerization Anatomical Structure Development Neuron Projection Development Regulation Of Cytoskeleton Organization Response To External Stimulus System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Developmental Process Regulation Of Cellular Component Size Antigen Receptor-mediated Signaling Pathway Regulation Of Protein Complex Assembly Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Organ Development Neuron Differentiation Actin Filament Capping Locomotion Negative Regulation Of Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization
Tagcloud ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 ugt1a1	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1