AP2S1 and RNF41

Number of citations of the paper that reports this interaction (PubMedID 29560723)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		AP2S1	RNF41
Description		adaptor related protein complex 2 subunit sigma 1	ring finger protein 41
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Synapse Clathrin-coated Endocytic Vesicle Presynapse Postsynapse	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731) Spondylosis ( 33332786)	Asthma ( 31619474) Height ( 34054925)
Interacting Genes		6 interacting genes: AAGAB AP2A1 AP2B1 CRIPTO RNF41 UBC	39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		1175	10193
HPRD ID		03762	11520
Ensembl ID		ENSG00000042753	ENSG00000181852
Uniprot IDs		M0QYZ2 M0R0N4 P53680 X6R390	F8VSB6 Q9H4P4
PDB IDs		6URI	2FZP 2GWF
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Endocytic Zone AP-2 Adaptor Complex Clathrin Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Coat Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Interleukin-3 Receptor Binding Synaptic Vesicle Nodal Binding Erythropoietin Receptor Binding Blood Vessel Development Positive Regulation Of Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Clathrin Coat Activin Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Heart Development Anterior/posterior Axis Specification, Embryo Protein Transport Nodal Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Endocytosis Golgi To Endosome Transport Cellular Response To Hepatocyte Growth Factor Stimulus Protein Tag Activity Response To Hepatocyte Growth Factor Cellular Response To Interleukin-6 Filopodium Tip Protein-containing Complex Binding Apical Plasma Membrane Establishment Of Protein Localization Clathrin Coat Assembly Response To Interleukin-6 Endoplasmic Reticulum Tubular Network	Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination
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