AP2S1 and AAGAB

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AP2S1	AAGAB
Gene Name		adaptor-related protein complex 2, sigma 1 subunit	alpha- and gamma-adaptin binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transporter Activity Protein Transporter Activity Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Clathrin Coat Assembly Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Protein Transport
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AAGAB AP2A1 AP2B1 TDGF1	5 interactors: AP1S3 AP2S1 EIF3C HEATR1 UNC119
Entrez ID		1175	79719
HPRD ID		03762	07754
Ensembl ID		ENSG00000042753	ENSG00000103591
Uniprot IDs		M0QYZ2 P53680	B4DG44 Q6PD74
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Ephrin Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Locomotion Protein Transport Antigen Processing And Presentation Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Receptor-mediated Endocytosis Cellular Response To Hepatocyte Growth Factor Stimulus Axon Guidance Cell Development Cellular Response To Organic Substance Protein Localization Golgi To Endosome Transport Immune System Process Axonogenesis Anterior/posterior Axis Specification, Embryo Viral Process Axon Development Cell Migration Involved In Sprouting Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Chemotaxis Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Interleukin-6 Endocytosis Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Regulation Of Defense Response To Virus By Virus Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Endocytosis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Caveolin-mediated Endocytosis Antigen Processing And Presentation Mitotic Cytokinetic Process Ribonucleoprotein Complex Biogenesis Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Vesicle-mediated Transport Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Regulation Of Transcription From RNA Polymerase I Promoter Formation Of Translation Preinitiation Complex Protein Localization Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Viral Process Synaptic Transmission Maturation Of SSU-rRNA Cellular Macromolecular Complex Assembly Endocytosis Clathrin Coat Assembly Positive Regulation Of Protein Tyrosine Kinase Activity Clathrin-mediated Endocytosis Ribosomal Small Subunit Biogenesis Mitotic Cytokinesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Membrane Organization Regulation Of Protein Tyrosine Kinase Activity Intracellular Protein Transport Cell-cell Signaling
Tagcloud ?		arg15leu argue attempting calcium casr catch causative feeding fhh fhh3 formula gna11 hypercalcemia hypercalciuria hyperparathyroidism hypocalciuria hypocalciuric imply infant infantile necessarily neoplasm payne played presumably pth pthrp sensing worth
Tagcloud (Difference) ?		arg15leu argue attempting calcium casr catch causative feeding fhh fhh3 formula gna11 hypercalcemia hypercalciuria hyperparathyroidism hypocalciuria hypocalciuric imply infant infantile necessarily neoplasm payne played presumably pth pthrp sensing worth
Tagcloud (Intersection) ?