AP2S1

Description		adaptor related protein complex 2 subunit sigma 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Synapse Clathrin-coated Endocytic Vesicle Presynapse Postsynapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
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Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731) Spondylosis ( 33332786)
Interacting Genes		6 interacting genes: AAGAB AP2A1 AP2B1 CRIPTO RNF41 UBC
Entrez ID		1175
HPRD ID		03762
Ensembl ID		ENSG00000042753
Uniprot IDs		M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs		6URI
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Endocytic Zone AP-2 Adaptor Complex Clathrin Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Coat Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Interleukin-3 Receptor Binding Synaptic Vesicle Nodal Binding Erythropoietin Receptor Binding Blood Vessel Development Positive Regulation Of Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Clathrin Coat Activin Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Heart Development Anterior/posterior Axis Specification, Embryo Protein Transport Nodal Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Endocytosis Golgi To Endosome Transport Cellular Response To Hepatocyte Growth Factor Stimulus Protein Tag Activity Response To Hepatocyte Growth Factor Cellular Response To Interleukin-6 Filopodium Tip Protein-containing Complex Binding Apical Plasma Membrane Establishment Of Protein Localization Clathrin Coat Assembly Response To Interleukin-6 Endoplasmic Reticulum Tubular Network
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