SH2D1B and PTK2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SH2D1B	PTK2
Description		SH2 domain containing 1B	protein tyrosine kinase 2
Image
GO Annotations	Cellular Component	Cytosol	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding ATP Binding JUN Kinase Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Molecular Function Activator Activity
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Angiogenesis Placenta Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cell-matrix Adhesion Heart Morphogenesis Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Cell Migration Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Detection Of Muscle Stretch Netrin-activated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Positive Regulation Of Wound Healing Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Macrophage Proliferation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Signal regulatory protein family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Endostatin 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE Fostamatinib
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30224653) LDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 27863252) Mood instability ( 31168069) Multisite chronic pain ( 33830993) Nickel levels ( 26025379) PR interval ( 32439900) Red cell distribution width ( 32888494) Response to interferon beta therapy ( 21502966) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	117 interacting genes: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 DOK4 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 HSPA13 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNB1 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 MISP MORC3 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PIK3R3 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SH2D1A SH2D1B SHC1 SKP2 SOCS1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TNS3 TP53 TRIM15 TRIO TRIP6 TSC2 VCL WEE2-AS1 YES1 ZFYVE21 ZNF331
Entrez ID		117157	5747
HPRD ID		12248	02859
Ensembl ID		ENSG00000198574	ENSG00000169398
Uniprot IDs		O14796	A0A8Q3WLM4 B4DWJ1 E5RFW9 E7ESA6 Q05397 Q59GM6 Q59GN8
PDB IDs		5KAZ	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S 6I8Z 6LES 6PW8 6YOJ 6YQ1 6YR9 6YT6 6YVS 6YVY 6YXV 7PI4 7W7Z 7W8B 7W8I 7W9U
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress	Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Signal Transduction Cell Migration Cell Motility Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Adhesion Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Cellular Component Organization Ruffle Membrane Integrin-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Immune System Process Protein Kinase Activity Intracellular Signal Transduction Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Protein Phosphorylation Receptor Complex Ephrin Receptor Signaling Pathway
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