SH2D1B and SLAMF1

Number of citations of the paper that reports this interaction (PMID 11689425)
15

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SH2D1B	SLAMF1
Gene Name		SH2 domain containing 1B	signaling lymphocytic activation molecule family member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	External Side Of Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Binding, Bridging	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Innate Immune Response	Signal Transduction Positive Regulation Of Cell Proliferation Viral Process Regulation Of Vesicle Fusion Lymphocyte Activation Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Schizophrenia (treatment refractory) ( 22479419)
Protein-Protein Interactions		8 interactors: APP CD244 CD84 ERBB2 LY9 PRDX1 SLAMF1 TRIM54	5 interactors: FGR FYN PTPN11 SH2D1A SH2D1B
Entrez ID		117157	6504
HPRD ID		12248	04603
Ensembl ID		ENSG00000198574	ENSG00000117090
Uniprot IDs		O14796	Q13291
PDB IDs			1D4T 1D4W 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5
Enriched GO Terms of Interacting Partners?		Immune System Process Wound Healing Response To Wounding Neuromuscular Junction Development Blood Coagulation Hemostasis Locomotion Defense Response Synaptic Growth At Neuromuscular Junction Regulation Of Body Fluid Levels Movement Of Cell Or Subcellular Component Collateral Sprouting In Absence Of Injury Negative Regulation Of Immature T Cell Proliferation In Thymus Synapse Organization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Innate Immune Response Axon Choice Point Recognition Response To Stress Leukocyte Migration Negative Regulation Of T Cell Differentiation In Thymus Neuron Remodeling Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Translation Positive Regulation Of Transcription From RNA Polymerase I Promoter	Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Fc Receptor Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Defense Response Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Response To Peptide T Cell Costimulation Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Wound Healing Ephrin Receptor Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Integrin-mediated Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Regulation Of Cell Shape Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cell Motility
Tagcloud ?			allelic c57bl cd4 cd8 congenic contrary copy enhancement hcd2 immature inversely isoform minigene nkrp1b nkt nkt1 nod numbers paradoxically selection subcongenic tcr tg thymic thymocytes transgene transgenic transgenically
Tagcloud (Difference) ?			allelic c57bl cd4 cd8 congenic contrary copy enhancement hcd2 immature inversely isoform minigene nkrp1b nkt nkt1 nod numbers paradoxically selection subcongenic tcr tg thymic thymocytes transgene transgenic transgenically
Tagcloud (Intersection) ?