SH2D1B and LY9

Number of citations of the paper that reports this interaction (PubMedID 11689425)
51

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SH2D1B	LY9
Description		SH2 domain containing 1B	lymphocyte antigen 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Adaptive Immune Response Immune System Process Immune Response Cell Adhesion Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response T-helper 17 Cell Lineage Commitment
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	3 interacting genes: AP2M1 SH2D1A SH2D1B
Entrez ID		117157	4063
HPRD ID		12248	02817
Ensembl ID		ENSG00000198574	ENSG00000122224
Uniprot IDs		O14796	A0A0C4DFU4 Q05CA2 Q0VAI0 Q5VYH9 Q9HBG7
PDB IDs		5KAZ
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress	Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Leukocyte Activation Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Positive Regulation Of Immune Effector Process Protein-macromolecule Adaptor Activity Regulation Of Lymphocyte Mediated Immunity Immune Response Adaptive Immune Response Positive Regulation Of Innate Immune Response AP-2 Adaptor Complex Clathrin Adaptor Complex Defense Response Clathrin Adaptor Activity Endolysosome Membrane Regulation Of Vesicle Size Immune Effector Process Lymphocyte Activation Clathrin-coated Endocytic Vesicle Regulation Of Synaptic Vesicle Endocytosis Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Receptor Internalization Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-dependent Endocytosis Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Receptor Signaling Pathway Vesicle Budding From Membrane Immune System Process Synaptic Vesicle Endocytosis Natural Killer Cell Mediated Cytotoxicity Presynaptic Endocytosis Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Immune Response Cellular Defense Response Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Natural Killer Cell Mediated Cytotoxicity
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