SH2D1B and CD84

Number of citations of the paper that reports this interaction (PubMedID 11689425)
51

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SH2D1B	CD84
Description		SH2 domain containing 1B	CD84 molecule
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GO Annotations	Cellular Component	Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Adaptive Immune Response Immune System Process Autophagy Defense Response Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation T Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Store-operated Calcium Entry
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	2 interacting genes: SH2D1A SH2D1B
Entrez ID		117157	8832
HPRD ID		12248	05151
Ensembl ID		ENSG00000198574	ENSG00000066294
Uniprot IDs		O14796	Q9UIB8
PDB IDs		5KAZ	2PKD
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress	Protein-macromolecule Adaptor Activity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Defense Response To Other Organism Defense Response To Symbiont Positive Regulation Of Lymphocyte Mediated Immunity Response To Other Organism Immune Response Defense Response Response To External Biotic Stimulus Protein Transport Into Plasma Membrane Raft Regulation Of Lymphocyte Mediated Immunity Protein Transport Into Membrane Raft Positive Regulation Of Immune Effector Process Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Potassium Ion Import P-type Sodium:potassium-exchanging Transporter Activity Immune System Process Positive Regulation Of Sodium Ion Export Across Plasma Membrane Protein Localization To Membrane Raft Immune Effector Process Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Transporter Activator Activity Sodium:potassium-exchanging ATPase Complex Regulation Of Innate Immune Response Positive Regulation Of Defense Response Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Potassium Ion Homeostasis Leukocyte Activation Relaxation Of Muscle Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cell Communication MHC Class II Protein Complex Binding Positive Regulation Of Immune Response Cell Activation ATPase Activator Activity Membrane Repolarization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
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