SH2D1B and STAT4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SH2D1B	STAT4
Description		SH2 domain containing 1B	signal transducer and activator of transcription 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Interleukin-6
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23291587 23001997) Celiac disease ( 22057235 30572963 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 26394269 28425483 23000144 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30572963 23143596 24390342 32723749 30423114 20453841) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 28076899 24097067 24097066) Systemic lupus erythematosus ( 32771030 28714469 33272962 19165918 23273568 18204098 19838193 19838195 21408207 23053960 24871463 26316170 26606652 26502338 27399966 26663301) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 33069728 20383147 29293537 21750679 31672989 21779181 30572963 24387989) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	13 interacting genes: ADRB2 CREBBP CRK IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 SH2D1B STAT3 ZNF467
Entrez ID		117157	6775
HPRD ID		12248	02779
Ensembl ID		ENSG00000198574	ENSG00000138378
Uniprot IDs		O14796	Q14765
PDB IDs		5KAZ
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress	Regulation Of Defense Response Immune System Process Cell Surface Receptor Signaling Pathway Interleukin-23-mediated Signaling Pathway Response To Stress NLRP1 Inflammasome Complex Assembly Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Interleukin-12-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Energy Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune Response Cellular Response To UV-B MAP Kinase Kinase Activity Cell Activation T-helper 1 Cell Differentiation Cellular Response To UV Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Light Stimulus Response To UV-B Stress-activated MAPK Cascade Negative Regulation Of Defense Response P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade SMAD Protein Signal Transduction Response To Muscle Stretch Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Immune System Process Response To Peptide Leukocyte Activation Canonical Inflammasome Complex Assembly Positive Regulation Of Erythrocyte Differentiation Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To UV Lipopolysaccharide-mediated Signaling Pathway T-helper Cell Differentiation Interleukin-12 Receptor Activity Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Pyroptotic Inflammatory Response Leukocyte Differentiation
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