SH2D1B and CD244

Number of citations of the paper that reports this interaction (PMID 11689425)
15

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SH2D1B	CD244
Gene Name		SH2 domain containing 1B	CD244 molecule, natural killer cell receptor 2B4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Binding, Bridging	Receptor Activity Protein Binding
	Biological Process	Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Innate Immune Response	Signal Transduction Blood Coagulation Leukocyte Migration
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: APP CD244 CD84 ERBB2 LY9 PRDX1 SLAMF1 TRIM54	5 interactors: ARHGEF7 CD247 CD48 LAT SH2D1B
Entrez ID		117157	51744
HPRD ID		12248	16121
Ensembl ID		ENSG00000198574	ENSG00000122223
Uniprot IDs		O14796	Q9BZW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune System Process Wound Healing Response To Wounding Neuromuscular Junction Development Blood Coagulation Hemostasis Locomotion Defense Response Synaptic Growth At Neuromuscular Junction Regulation Of Body Fluid Levels Movement Of Cell Or Subcellular Component Collateral Sprouting In Absence Of Injury Negative Regulation Of Immature T Cell Proliferation In Thymus Synapse Organization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Innate Immune Response Axon Choice Point Recognition Response To Stress Leukocyte Migration Negative Regulation Of T Cell Differentiation In Thymus Neuron Remodeling Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Translation Positive Regulation Of Transcription From RNA Polymerase I Promoter	Immune System Process Regulation Of Cell Adhesion Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Lamellipodium Morphogenesis Fc Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Positive Regulation Of Fibroblast Migration Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Lamellipodium Organization Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Mast Cell Degranulation Regulation Of Body Fluid Levels Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Wound Healing Mast Cell Mediated Immunity Small GTPase Mediated Signal Transduction Focal Adhesion Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Lysosome Localization Mast Cell Activation Cell Activation Response To Wounding Leukocyte Degranulation Lamellipodium Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Assembly Lamellipodium Organization Negative Regulation Of ERBB Signaling Pathway
Tagcloud ?			accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital
Tagcloud (Difference) ?			accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital
Tagcloud (Intersection) ?