FCHO2 and EPS15

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FCHO2	EPS15
Description		FCH and mu domain containing endocytic adaptor 2	epidermal growth factor receptor pathway substrate 15
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Synapse Presynapse	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 32888494 27863252) Serum albumin levels ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)
Interacting Genes		6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC	62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1
Entrez ID		115548	2060
HPRD ID		13319	08968
Ensembl ID		ENSG00000157107	ENSG00000085832
Uniprot IDs		Q0JRZ9	A0A994J5A3 A0A994J5J3 B7Z240 P42566
PDB IDs		2V0O 7OG1 7OHO 7OHZ 7OI5 7OIQ 7OIT	1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endocytosis Protein-macromolecule Adaptor Activity Import Into Cell Clathrin Coat Of Coated Pit Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Clathrin Coat Assembly Vesicle-mediated Transport Receptor-mediated Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Clathrin-coated Vesicle Leading Edge Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Aldosterone Secretion Calcium Ion Binding Positive Regulation Of Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Endocytosis Plasma Membrane Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Hormone Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Postsynaptic Neurotransmitter Receptor Internalization Ubiquitin-dependent Endocytosis Guanyl-nucleotide Exchange Factor Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Focal Adhesion Disassembly Postsynaptic Actin Cytoskeleton Regulation Of Protein Localization AP-2 Adaptor Complex Regulation Of Hormone Secretion Cytosol Receptor-mediated Endocytosis Of Virus By Host Cell Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Secretion By Cell Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure	Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process
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