FCHO2

Description		FCH and mu domain containing endocytic adaptor 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Synapse Presynapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Endocytosis Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 32888494 27863252) Serum albumin levels ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Novel Interacting Genes		1 novel interacting genes: MRPS27
Interacting Genes		6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC
Entrez ID		115548
HPRD ID		13319
Ensembl ID		ENSG00000157107
Uniprot IDs		Q0JRZ9
PDB IDs		2V0O 7OG1 7OHO 7OHZ 7OI5 7OIQ 7OIT
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endocytosis Protein-macromolecule Adaptor Activity Import Into Cell Clathrin Coat Of Coated Pit Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Clathrin Coat Assembly Vesicle-mediated Transport Receptor-mediated Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Clathrin-coated Vesicle Leading Edge Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Aldosterone Secretion Calcium Ion Binding Positive Regulation Of Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Endocytosis Plasma Membrane Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Hormone Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Postsynaptic Neurotransmitter Receptor Internalization Ubiquitin-dependent Endocytosis Guanyl-nucleotide Exchange Factor Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Focal Adhesion Disassembly Postsynaptic Actin Cytoskeleton Regulation Of Protein Localization AP-2 Adaptor Complex Regulation Of Hormone Secretion Cytosol Receptor-mediated Endocytosis Of Virus By Host Cell Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Secretion By Cell Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure
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