FCHO2 and DAB2

Number of citations of the paper that reports this interaction (PMID 22323290)
4

Data Source:
BioGRID (pull down)

		FCHO2	DAB2
Gene Name		FCH domain only 2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Coated Pit Clathrin-coated Vesicle	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Membrane Invagination Clathrin Coat Assembly Clathrin-mediated Endocytosis Protein Localization To Plasma Membrane	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		1 interactors: DAB2	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		115548	1601
HPRD ID		13319	03139
Ensembl ID		ENSG00000157107	ENSG00000153071
Uniprot IDs		Q0JRZ9	B2RAW0 P98082
PDB IDs		2V0O	2LSW
Enriched GO Terms of Interacting Partners?		Leading Edge Cell Differentiation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Androgen Receptor Signaling Pathway Pinocytosis Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Receptor Recycling Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Receptor Recycling Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Epithelial To Mesenchymal Transition Clathrin Coat Assembly Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of JUN Kinase Activity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Excretion Regulation Of Protein Localization To Plasma Membrane Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Protein Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding Regulation Of JUN Kinase Activity Endoderm Development JNK Cascade Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Binding Positive Regulation Of Endocytosis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?			associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?			associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?