DDIT4L and FHIT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDIT4L	FHIT
Description		DNA damage inducible transcript 4 like	fragile histidine triad diadenosine triphosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Fibrillar Center Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Protein Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Adenosine 5'-monophosphoramidase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Adenylylsulfatase Activity Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Negative Regulation Of Signal Transduction	Purine Nucleotide Metabolic Process Apoptotic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways
Drugs			Adenosine monotungstate Ado-P-Ch2-P-Ps-Ado
Diseases			Small cell lung cancer Non-small cell lung cancer
GWAS		Alcohol consumption (drinks per week) ( 30643258) Nose size ( 27182965)	Adult body size ( 32376654) Adverse response to lamotrigine and phenytoin ( 22379998) Age at first sexual intercourse ( 34211149) Aortic root size ( 21223598) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 28552196 28448500 26961502 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Broad depression or schizophrenia ( 30626913) Bronchopulmonary dysplasia ( 23897914) Caudal anterior-cingulate cortex volume ( 31530798) Cognitive function ( 25644384) Conotruncal heart defects ( 24800985) Depressive symptom measurement or major depressive disorder ( 28049566) Differentiated thyroid cancer ( 28703219) Falling risk ( 32999390) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Intracranial aneurysm ( 29531279) Iris color (L* coordinate) ( 30895295) Irritable bowel syndrome ( 29673008) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lung function (maximal voluntary ventilation) ( 29095316) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643) Major depressive disorder ( 20125088) Methadone dose in opioid dependence ( 28115739) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Papillary thyroid cancer ( 28703219) Pars triangularis volume ( 31530798) Photic sneeze reflex ( 27182965) Postoperative myocardial infarction after cardiac surgery ( 30678657) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553) Schizophrenia ( 30285260) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		155 interacting genes: ABCB11 ACY3 AFMID AIDA AKT1 ARK2N ARPIN BAG4 BANF2 BCL2L14 BID C14orf119 C19orf25 C5orf22 CABP5 CALCOCO2 CALM1 CALM2 CALM3 CATIP CCNK CDA CDKN2D CDPF1 CHMP1A CLIC3 CLK2 CLK3 CPNE7 CRLF3 CRYBB1 DBI DNPH1 DUSP23 DUSP29 EIF4A3 EIF4EBP1 EIF4H EPHB6 EXOSC1 EXOSC5 EXOSC8 FAAP20 FADD FAM200C FHIT FHL2 FKBP6 FLNA GADD45G GEMIN6 GPKOW GRB2 GUCA1A HDAC7 HMG20A HSPB7 IL36RN IMPDH1 KANK2 KCTD9 KDM8 KRT34 KRTAP5-6 LENG1 LGALS14 LGALSL LMO1 LRATD2 LSM3 LSM5 LSM7 MAP3K7CL MAPRE2 MAPRE3 MEMO1 MIEN1 MKRN3 MLX MORF4L2 MT1M MYG1 MYLIP NAA10 NAV1 NEK6 NGB NHLRC4 NME7 NQO2 NR2C2AP NUDT2 NUDT22 NXT2 PARVG PCBP3 PDE4C PFKFB1 PLSCR4 PM20D2 PMVK PPCDC PPIL1 PPP1R27 PRKAB2 PRPF40A PSMA1 PSMB9 PTS PUF60 RAB32 RFC5 RFPL3 RPIA RPL22 RPRD1B SCOC SEC22A SEPTIN1 SEPTIN3 SEPTIN5 SH3BGRL3 SNRPA SNRPG SREK1IP1 STK16 STK4 SULT2B1 TBC1D22B TCL1A TCP11L1 TEKT4 TEX14 TFPT TNS2 TOLLIP TRIM73 TSEN15 TSSK3 TTC5 TXN TXNL4A TYW3 UBASH3A UBTFL1 VBP1 VCX2 VPS26C YES1 YOD1 YPEL5 ZNF593 ZNF76 ZNF765 ZSCAN23	13 interacting genes: BCAS2 CTNNB1 DDIT4L FDXR GSN HSPD1 PRPF6 RAB40B REL SRC TRIM23 UBE2I YTHDF1
Entrez ID		115265	2272
HPRD ID		09663	03096
Ensembl ID		ENSG00000145358	ENSG00000189283
Uniprot IDs		Q96D03	P49789
PDB IDs			1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT 7P8P
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Nucleus MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Identical Protein Binding Cytosol U4/U6 X U5 Tri-snRNP Complex MRNA Processing RNA Splicing Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Lsm1-7-Pat1 Complex RNA Processing Nucleobase-containing Compound Metabolic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Lsm2-8 Complex Protein Serine/threonine Kinase Activator Activity Spliceosomal Complex U6 SnRNP Protein Kinase Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Nucleoplasm Titin Binding Septin Ring Septin Complex Cell Division Site Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Detection Of Calcium Ion Nucleobase-containing Compound Catabolic Process Regulation Of Cell Communication By Electrical Coupling Nuclear Exosome (RNase Complex) U2-type Prespliceosome Exosome (RNase Complex) Phosphate-containing Compound Metabolic Process Protein Phosphatase Activator Activity Microtubule Cytoskeleton Calyx Of Held U1 SnRNP RNA Metabolic Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Regulator Activity	Bone Resorption Response To Muscle Stretch Oocyte Development Cellular Component Assembly Regulation Of Podosome Assembly Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Post-translational Protein Modification Immune System Process Protein Metabolic Process Germ Cell Development Lamellipodium Enzyme Binding Glial Cell Fate Determination Transcription Coregulator Binding Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Ferredoxin-NADP+ Reductase Activity Response To Cytokine Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Podosome Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Oogenesis Regulation Of Lamellipodium Organization SUMO Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Response To Peptide Regulation Of Protein Processing Protein Destabilization Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Epidermal Growth Factor Receptor Signaling Pathway Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Protein Catabolic Process Forebrain Development Regulation Of Protein Maturation Positive Regulation Of Protein Processing In Phagocytic Vesicle Female Gamete Generation Protein Modification By Small Protein Conjugation
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