DDIT4L and TTC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDIT4L	TTC5
Description		DNA damage inducible transcript 4 like	tetratricopeptide repeat domain 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Ribosome Binding
	Biological Process	Negative Regulation Of Signal Transduction	DNA Repair DNA Damage Response Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process
Pathways			Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Nose size ( 27182965)	Alzheimer's disease progression score ( 29860282)
Interacting Genes		155 interacting genes: ABCB11 ACY3 AFMID AIDA AKT1 ARK2N ARPIN BAG4 BANF2 BCL2L14 BID C14orf119 C19orf25 C5orf22 CABP5 CALCOCO2 CALM1 CALM2 CALM3 CATIP CCNK CDA CDKN2D CDPF1 CHMP1A CLIC3 CLK2 CLK3 CPNE7 CRLF3 CRYBB1 DBI DNPH1 DUSP23 DUSP29 EIF4A3 EIF4EBP1 EIF4H EPHB6 EXOSC1 EXOSC5 EXOSC8 FAAP20 FADD FAM200C FHIT FHL2 FKBP6 FLNA GADD45G GEMIN6 GPKOW GRB2 GUCA1A HDAC7 HMG20A HSPB7 IL36RN IMPDH1 KANK2 KCTD9 KDM8 KRT34 KRTAP5-6 LENG1 LGALS14 LGALSL LMO1 LRATD2 LSM3 LSM5 LSM7 MAP3K7CL MAPRE2 MAPRE3 MEMO1 MIEN1 MKRN3 MLX MORF4L2 MT1M MYG1 MYLIP NAA10 NAV1 NEK6 NGB NHLRC4 NME7 NQO2 NR2C2AP NUDT2 NUDT22 NXT2 PARVG PCBP3 PDE4C PFKFB1 PLSCR4 PM20D2 PMVK PPCDC PPIL1 PPP1R27 PRKAB2 PRPF40A PSMA1 PSMB9 PTS PUF60 RAB32 RFC5 RFPL3 RPIA RPL22 RPRD1B SCOC SEC22A SEPTIN1 SEPTIN3 SEPTIN5 SH3BGRL3 SNRPA SNRPG SREK1IP1 STK16 STK4 SULT2B1 TBC1D22B TCL1A TCP11L1 TEKT4 TEX14 TFPT TNS2 TOLLIP TRIM73 TSEN15 TSSK3 TTC5 TXN TXNL4A TYW3 UBASH3A UBTFL1 VBP1 VCX2 VPS26C YES1 YOD1 YPEL5 ZNF593 ZNF76 ZNF765 ZSCAN23	9 interacting genes: CAMK2A CAMK2B CAMK2D CAMK2G CAVIN1 DDIT4L GOLGA6A HDX JMY
Entrez ID		115265	91875
HPRD ID		09663	15584
Ensembl ID		ENSG00000145358	ENSG00000136319
Uniprot IDs		Q96D03	Q86T04 Q8N0Z6
PDB IDs			2XVS 6T59 7QWS 8BPO
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Nucleus MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Identical Protein Binding Cytosol U4/U6 X U5 Tri-snRNP Complex MRNA Processing RNA Splicing Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Lsm1-7-Pat1 Complex RNA Processing Nucleobase-containing Compound Metabolic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Lsm2-8 Complex Protein Serine/threonine Kinase Activator Activity Spliceosomal Complex U6 SnRNP Protein Kinase Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Nucleoplasm Titin Binding Septin Ring Septin Complex Cell Division Site Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Detection Of Calcium Ion Nucleobase-containing Compound Catabolic Process Regulation Of Cell Communication By Electrical Coupling Nuclear Exosome (RNase Complex) U2-type Prespliceosome Exosome (RNase Complex) Phosphate-containing Compound Metabolic Process Protein Phosphatase Activator Activity Microtubule Cytoskeleton Calyx Of Held U1 SnRNP RNA Metabolic Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Regulator Activity	Calcium- And Calmodulin-dependent Protein Kinase Complex Calcium/calmodulin-dependent Protein Kinase Activity Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Periphery Sarcoplasmic Reticulum Membrane Regulation Of Protein Localization To Membrane Calmodulin Binding Regulation Of Synaptic Plasticity Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Postsynaptic Density Regulation Of Skeletal Muscle Adaptation Neuron Projection Regulation Of Metal Ion Transport Protein Serine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Monoatomic Ion Transport Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cellular Localization Kinase Activity Regulation Of Muscle System Process Regulation Of Neuron Migration Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Homodimerization Activity Peptidyl-threonine Autophosphorylation 'de Novo' Actin Filament Nucleation Protein Phosphorylation Regulation Of Protein Localization Phosphorylation Identical Protein Binding Regulation Of Endocannabinoid Signaling Pathway Calcium-dependent Protein Serine/threonine Phosphatase Activity Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Protein Autophosphorylation Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Relaxation Of Cardiac Muscle Glutamate Receptor Binding
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