RHPN1 and CNKSR1

Number of citations of the paper that reports this interaction (PMID 14749388)
16

Data Source:
HPRD (in vivo, in vitro)

		RHPN1	CNKSR1
Gene Name		rhophilin, Rho GTPase binding protein 1	connector enhancer of kinase suppressor of Ras 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Small GTPase Regulator Activity	Protein Binding, Bridging
	Biological Process	Signal Transduction Regulation Of Catalytic Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CALCOCO2 CNKSR1 EFEMP2 KRT15 MTUS2 RHOA ROPN1 TRIM27 TRIM37	18 interactors: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SMAD4 STK3 STK4 ZDHHC17
Entrez ID		114822	10256
HPRD ID		17973	11937
Ensembl ID		ENSG00000158106	ENSG00000142675
Uniprot IDs		Q8TCX5	Q53GM7 Q969H4
PDB IDs			1WWV
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Interleukin-2 Secretion Histone H2A-K119 Monoubiquitination Skeletal Muscle Satellite Cell Migration Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Centriole Replication Negative Regulation Of Calcium Ion Import Apolipoprotein A-I-mediated Signaling Pathway Ras Protein Signal Transduction Regulation Of Organelle Organization Cleavage Furrow Formation	Regulation Of Signal Transduction Regulation Of Signaling Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Signaling Endocardium Development Small GTPase Mediated Signal Transduction Cell Communication Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Protein Autophosphorylation Primitive Hemopoiesis Response To Stimulus Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process
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