HTR2C and TMEM94

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR2C	TMEM94
Description		5-hydroxytryptamine receptor 2C	transmembrane protein 94
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	P-type Magnesium Transporter Activity
	Biological Process	Behavioral Fear Response Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Monoatomic Ion Transport Intracellular Magnesium Ion Homeostasis Magnesium Ion Transport From Cytosol To Endoplasmic Reticulum
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Flupentixol Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Pimavanserin Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Nandrolone decanoate Captodiame Viloxazine Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS
Interacting Genes		34 interacting genes: APBA1 ARLN ARRB2 ATP2B3 ATP6AP2 ATP6V0C CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SLC71A1 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1	5 interacting genes: BUD31 GPR35 HTR2C LTB4R2 MC4R
Entrez ID		3358	9772
HPRD ID		02429	11068
Ensembl ID		ENSG00000147246	ENSG00000177728
Uniprot IDs		K9J958 P28335	B7Z9U5 J3QLC5 J3QRY7 J3QSG7 Q12767
PDB IDs		6BQG 6BQH 8DPF 8DPG 8DPH 8DPI 8ZMF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Plasma Membrane Transmembrane Transport Cellular Homeostasis Intracellular Chemical Homeostasis Homeostatic Process Chemical Homeostasis Synapse Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Cation Transmembrane Transport Endoplasmic Reticulum PDZ Domain Binding Monoatomic Cation Transmembrane Transport Ubiquitin Protein Ligase Binding Monoatomic Cation Homeostasis Regulation Of Lysosomal Lumen PH Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Ion Transport D1 Dopamine Receptor Binding Monoatomic Cation Transport Glutamatergic Synapse Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Regulation Of Membrane Potential Neuron Cellular Homeostasis Glutamate Secretion Endosomal Lumen Acidification G Protein-coupled Receptor Binding Dystrophin-associated Glycoprotein Complex Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Regulation Of Intracellular PH Bounding Membrane Of Organelle Regulation Of Cellular PH Regulation Of System Process Metal Ion Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Regulation Of Biological Quality Metal Ion Transport Regulation Of PH Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Cytokine Production Postsynapse Lysosomal Lumen Acidification Anchoring Junction Zinc Ion Transmembrane Transport	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Feeding Behavior Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Melanocyte-stimulating Hormone Receptor Activity Response To Melanocyte-stimulating Hormone Leukotriene B4 Receptor Activity Leukotriene Receptor Activity G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Leukotriene Signaling Pathway Melanocortin Receptor Activity Keratinocyte Migration C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Eating Behavior Serotonin Binding Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Positive Regulation Of Bone Resorption Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Chemokine Receptor Activity Regulation Of Appetite Negative Regulation Of Transporter Activity Neuropeptide Binding Regulation Of Feeding Behavior
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