HTR2C

Gene Name		5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Drug Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Behavioral Fear Response CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Fenfluramine Lisuride Trazodone Apomorphine Risperidone Propiomazine Minaprine Tegaserod Doxepin Nefazodone Pergolide Dexfenfluramine Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine 3,4-Methylenedioxymethamphetamine Lorcaserin Sertindole Mianserin Asenapine Agomelatine
Diseases
GWAS
Protein-protein Interactions		8 interactors: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1
Entrez ID		3358
HPRD ID		02429
Ensembl ID		ENSG00000147246
Uniprot IDs		K9J958 P28335
PDB IDs
Enriched GO Terms of Interacting Partners?		Maintenance Of Apical/basal Cell Polarity Maintenance Of Cell Polarity Secretion By Cell Nervous System Development Behavior Platelet Activation Regulation Of Ion Transport Secretion Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Receptor Internalization Locomotory Behavior Regulation Of Membrane Potential Negative Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cell-cell Signaling Exocytosis Positive Regulation Of Phospholipase C Activity Developmental Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Action Potential Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Synaptic Transmission System Development Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Body Fluid Levels Synaptic Transmission Vesicle-mediated Transport Wound Healing Establishment Of Protein Localization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Activation Regulation Of Muscle Contraction Multicellular Organismal Development Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Tagcloud ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a