HTR2C and LIN7C

Number of citations of the paper that reports this interaction (PMID 12006486)
23

Data Source:
HPRD (in vivo)

		HTR2C	LIN7C
Gene Name		5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	lin-7 homolog C (C. elegans)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Postsynaptic Density Basolateral Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Drug Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Behavioral Fear Response CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Fenfluramine Lisuride Trazodone Apomorphine Risperidone Propiomazine Minaprine Tegaserod Doxepin Nefazodone Pergolide Dexfenfluramine Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine 3,4-Methylenedioxymethamphetamine Lorcaserin Sertindole Mianserin Asenapine Agomelatine
Diseases
GWAS			Bone mineral density ( 22504420)
Protein-Protein Interactions		8 interactors: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1	4 interactors: ABCA1 BAIAP2 HTR2C KCNJ12
Entrez ID		3358	55327
HPRD ID		02429	17279
Ensembl ID		ENSG00000147246	ENSG00000148943
Uniprot IDs		K9J958 P28335	Q9NUP9
PDB IDs			3LRA
Enriched GO Terms of Interacting Partners?		Maintenance Of Apical/basal Cell Polarity Maintenance Of Cell Polarity Secretion By Cell Nervous System Development Behavior Platelet Activation Regulation Of Ion Transport Secretion Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Receptor Internalization Locomotory Behavior Regulation Of Membrane Potential Negative Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cell-cell Signaling Exocytosis Positive Regulation Of Phospholipase C Activity Developmental Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Action Potential Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Synaptic Transmission System Development Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Body Fluid Levels Synaptic Transmission Vesicle-mediated Transport Wound Healing Establishment Of Protein Localization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Activation Regulation Of Muscle Contraction Multicellular Organismal Development Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity	Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Interleukin-1 Beta Secretion Phagocytosis Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Interleukin-1 Secretion Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Ion Transport Platelet Dense Granule Organization Response To External Stimulus Endomembrane System Organization Cellular Component Assembly Response To Nutrient Levels Phospholipid Efflux Phagocytosis, Engulfment Transport Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Response To Extracellular Stimulus Response To Bacterium Serotonin Receptor Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Response To Drug Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Actin Crosslink Formation Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Signaling Ion Homeostasis Positive Regulation Of Cholesterol Transport CGMP Biosynthetic Process Cell Communication Synaptic Transmission Regulation Of Appetite Regulation Of Cholesterol Efflux Response To Cholesterol Potassium Ion Import
Tagcloud ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kctd15 kong loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist
Tagcloud (Difference) ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kctd15 kong loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist
Tagcloud (Intersection) ?