HTR2C and GPRC5B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR2C	GPRC5B
Description		5-hydroxytryptamine receptor 2C	G protein-coupled receptor class C group 5 member B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Extracellular Space Nucleoplasm Nucleolus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Kinase Binding Protein Kinase Activator Activity Protein Tyrosine Kinase Binding
	Biological Process	Behavioral Fear Response Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Flupentixol Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Pimavanserin Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Nandrolone decanoate Captodiame Viloxazine Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 20935630 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Hip circumference ( 25673412) L-selectin levels ( 25576479) Menarche (age at onset) ( 25231870) Obesity ( 23563607) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		34 interacting genes: APBA1 ARLN ARRB2 ATP2B3 ATP6AP2 ATP6V0C CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SLC71A1 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1	6 interacting genes: ADRB2 C11orf71 FUCA2 HTR2C TMEM120A TSG101
Entrez ID		3358	51704
HPRD ID		02429	16177
Ensembl ID		ENSG00000147246	ENSG00000167191
Uniprot IDs		K9J958 P28335	B7Z831 Q9NZH0
PDB IDs		6BQG 6BQH 8DPF 8DPG 8DPH 8DPI 8ZMF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Plasma Membrane Transmembrane Transport Cellular Homeostasis Intracellular Chemical Homeostasis Homeostatic Process Chemical Homeostasis Synapse Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Cation Transmembrane Transport Endoplasmic Reticulum PDZ Domain Binding Monoatomic Cation Transmembrane Transport Ubiquitin Protein Ligase Binding Monoatomic Cation Homeostasis Regulation Of Lysosomal Lumen PH Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Ion Transport D1 Dopamine Receptor Binding Monoatomic Cation Transport Glutamatergic Synapse Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Regulation Of Membrane Potential Neuron Cellular Homeostasis Glutamate Secretion Endosomal Lumen Acidification G Protein-coupled Receptor Binding Dystrophin-associated Glycoprotein Complex Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Regulation Of Intracellular PH Bounding Membrane Of Organelle Regulation Of Cellular PH Regulation Of System Process Metal Ion Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Regulation Of Biological Quality Metal Ion Transport Regulation Of PH Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Cytokine Production Postsynapse Lysosomal Lumen Acidification Anchoring Junction Zinc Ion Transmembrane Transport	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Fat Cell Differentiation Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Nervous System Process Lysosomal Transport Endosome To Lysosome Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Alpha-L-fucosidase Activity HSP90-CDC37 Chaperone Complex Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Response To Psychosocial Stress Norepinephrine Binding Vacuolar Transport Positive Regulation Of Lipophagy Response To Temperature Stimulus AMPA Selective Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Exosomal Secretion Coenzyme A Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Regulation Of Extracellular Exosome Assembly Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Entry Of Bacterium Into Host Cell Glycoside Catabolic Process ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Adrenergic Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Serotonin Binding Serotonin Receptor Signaling Pathway Virion Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Adhesion Of Symbiont To Host Cell
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