PHB2 and PTMA

Number of citations of the paper that reports this interaction (PubMedID 12943695)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PHB2	PTMA
Description		prohibitin 2	prothymosin alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Nuclear Matrix Protein-containing Complex Mitochondrial Prohibitin Complex Cell Periphery Inner Mitochondrial Membrane Protein Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity	Protein Binding Histone Binding DNA-binding Transcription Factor Binding Histone Chaperone Activity
	Biological Process	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Cell Migration Regulation Of Complement Activation Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cytochrome-c Oxidase Activity	Chromatin Organization DNA-templated Transcription Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Processing of SMDT1 Cellular response to mitochondrial stress
Drugs		Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Glycated hemoglobin levels ( 28898252 34059833) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		26 interacting genes: AFP AKT1 ANXA1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PRKN PTEN PTMA RNF2 TEAD3 UPF2 VHL	43 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 FNDC3B GSK3A H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17
Entrez ID		11331	5757
HPRD ID		17843	01778
Ensembl ID		ENSG00000215021	ENSG00000187514
Uniprot IDs		A0A7I2V5F0 Q99623	P06454 Q53S24
PDB IDs		6IQE 8J4I 8RRH	2L9I 2MNQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Enzyme Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Developmental Process Positive Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Binding Negative Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Protein Lysine Deacetylase Activity Protein Lysine Delactylase Activity Transcription Corepressor Binding Response To Hormone Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Histone Deacetylase Binding Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process	Nucleoplasm Chromatin Organization Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Protein Localization To Organelle Chromosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Protein-containing Complex Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Import Into Nucleus Rhythmic Process Negative Regulation Of Biosynthetic Process Chromosome Import Into Nucleus Telomere Organization Protein-DNA Complex Assembly Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Nuclear Telomere Cap Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleosome Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Programmed Cell Death DNA Binding
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