PHB2 and TEAD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PHB2	TEAD3
Description		prohibitin 2	TEA domain transcription factor 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Nuclear Matrix Protein-containing Complex Mitochondrial Prohibitin Complex Cell Periphery Inner Mitochondrial Membrane Protein Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Nuclear Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Cell Migration Regulation Of Complement Activation Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cytochrome-c Oxidase Activity	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Female Pregnancy Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Asymmetric Neuroblast Division
Pathways		Processing of SMDT1 Cellular response to mitochondrial stress	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Regulation of PD-L1(CD274) transcription
Drugs		Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Glycated hemoglobin levels ( 28898252 34059833) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Offspring birth weight ( 31043758)
Interacting Genes		26 interacting genes: AFP AKT1 ANXA1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PRKN PTEN PTMA RNF2 TEAD3 UPF2 VHL	14 interacting genes: AP4S1 CTBP2 E2F1 E2F3 KIFC2 MYH7 PHB2 PIDD1 SUMO2 VGLL1 VGLL2 VGLL3 WWTR1 YAP1
Entrez ID		11331	7005
HPRD ID		17843	04411
Ensembl ID		ENSG00000215021	ENSG00000007866
Uniprot IDs		A0A7I2V5F0 Q99623	A0A7P0SNI2 Q99594
PDB IDs		6IQE 8J4I 8RRH	5EMW 7CNL 7ZJQ 8P0M
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Enzyme Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Developmental Process Positive Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Binding Negative Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Protein Lysine Deacetylase Activity Protein Lysine Delactylase Activity Transcription Corepressor Binding Response To Hormone Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Histone Deacetylase Binding Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process	Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fat Cell Differentiation DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Hippo Signaling Heart Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Gene Expression Enterocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of The Force Of Skeletal Muscle Contraction Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Osteoblast Differentiation Mitochondrial Prohibitin Complex Nucleus Cis-regulatory Region Sequence-specific DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation TEAD-YAP Complex Regulation Of Cytochrome-c Oxidase Activity Amide Binding Endopeptidase Complex Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Signal Transduction By P53 Class Mediator Lens Fiber Cell Apoptotic Process Lateral Mesoderm Development
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