PHB2 and AFP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PHB2	AFP
Gene Name		prohibitin 2	alpha-fetoprotein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Nuclear Matrix Protein Complex Extracellular Vesicular Exosome	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Estrogen Receptor Binding	Metal Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Transcription, DNA-templated Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Protein-Protein Interactions		19 interactors: AFP AKT1 ARFGEF3 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PTMA RNF2 TEAD3 UPF2	10 interactors: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP
Entrez ID		11331	174
HPRD ID		17843	00074
Ensembl ID		ENSG00000215021	ENSG00000081051
Uniprot IDs		Q99623	P02771
PDB IDs			3MRK
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Histone H4 Deacetylation Organ Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Development Histone H3 Deacetylation Response To Organic Cyclic Compound Chromatin Modification Regulation Of Striated Muscle Cell Differentiation Histone Modification Cellular Response To Organic Cyclic Compound Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3-K9 Modification Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Chromatin Organization Response To Organic Substance Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Rhythmic Process Regulation Of Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Signal Transduction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Programmed Cell Death Regulation Of Signaling Cell Death Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Homeostasis Positive Regulation Of Protein Linear Polyubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Late Endosome To Golgi Transport Ion Homeostasis Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Mitotic Cell Cycle Checkpoint Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Cytosolic Calcium Ion Homeostasis Cardiac Muscle Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Apoptotic Process Regulation Of Protein Ubiquitination Endosomal Transport Regulation Of Cysteine-type Endopeptidase Activity Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		backgroundidentification caspases conclusionsour delineate elucidating hodgkin hubs imperative interactome interactors inverted lentiviral lymphomagenesis lymphomas manipulate mark mcc methodswe nhl oncogenes parp1 premalignant question resultswe sharp splenic strikingly suppressive traf3	acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Difference) ?		backgroundidentification caspases conclusionsour delineate elucidating hodgkin hubs imperative interactome interactors inverted lentiviral lymphomagenesis lymphomas manipulate mark mcc methodswe nhl oncogenes parp1 premalignant question resultswe sharp splenic strikingly suppressive traf3	acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Intersection) ?