PHB2 and MYOD1

Number of citations of the paper that reports this interaction (PubMedID 15173318)
0

Data Source:
HPRD (in vivo)

		PHB2	MYOD1
Description		prohibitin 2	myogenic differentiation 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Nuclear Matrix Protein-containing Complex Mitochondrial Prohibitin Complex Cell Periphery Inner Mitochondrial Membrane Protein Complex	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Myofibril
	Molecular Function	Protein Binding Nuclear Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Cell Migration Regulation Of Complement Activation Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cytochrome-c Oxidase Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Tissue Development Regulation Of Gene Expression Myotube Differentiation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		Processing of SMDT1 Cellular response to mitochondrial stress	Myogenesis Myogenesis TGFBR3 expression
Drugs		Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Glycated hemoglobin levels ( 28898252 34059833) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		26 interacting genes: AFP AKT1 ANXA1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PRKN PTEN PTMA RNF2 TEAD3 UPF2 VHL	67 interacting genes: AKAP19 AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		11331	4654
HPRD ID		17843	01166
Ensembl ID		ENSG00000215021	ENSG00000129152
Uniprot IDs		A0A7I2V5F0 Q99623	P15172
PDB IDs		6IQE 8J4I 8RRH
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Enzyme Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Developmental Process Positive Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Binding Negative Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Protein Lysine Deacetylase Activity Protein Lysine Delactylase Activity Transcription Corepressor Binding Response To Hormone Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Histone Deacetylase Binding Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of Macromolecule Metabolic Process BHLH Transcription Factor Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Nucleoplasm Histone Deacetylase Binding Regulation Of Developmental Process E-box Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Differentiation Cell Differentiation Regulation Of Metabolic Process Circadian Rhythm Positive Regulation Of Cell Differentiation Cellular Developmental Process Transcription Cis-regulatory Region Binding Negative Regulation Of Developmental Process
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