PHB2 and NR2F2

Number of citations of the paper that reports this interaction (PMID 15140878)
29

Data Source:
BioGRID (pull down)

		PHB2	NR2F2
Gene Name		prohibitin 2	nuclear receptor subfamily 2, group F, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Nuclear Matrix Protein Complex Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Protein Binding Estrogen Receptor Binding	Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Transcription, DNA-templated Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Signal Transduction Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		19 interactors: AFP AKT1 ARFGEF3 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PTMA RNF2 TEAD3 UPF2	19 interactors: BCL11A BCL11B BIK EP300 FAM46A HDAC1 HIPK3 LCK MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TRIM24 TRIP4
Entrez ID		11331	7026
HPRD ID		17843	00139
Ensembl ID		ENSG00000215021	ENSG00000185551
Uniprot IDs		Q99623	F1D8R0 P24468
PDB IDs			3CJW
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Histone H4 Deacetylation Organ Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Development Histone H3 Deacetylation Response To Organic Cyclic Compound Chromatin Modification Regulation Of Striated Muscle Cell Differentiation Histone Modification Cellular Response To Organic Cyclic Compound Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3-K9 Modification Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Chromatin Organization Response To Organic Substance Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Rhythmic Process Regulation Of Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Peptidyl-amino Acid Modification Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Hormone Chromatin Modification Response To Organic Substance Cellular Protein Modification Process Regulation Of Apoptotic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Histone Modification Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Death
Tagcloud ?		backgroundidentification caspases conclusionsour delineate elucidating hodgkin hubs imperative interactome interactors inverted lentiviral lymphomagenesis lymphomas manipulate mark mcc methodswe nhl oncogenes parp1 premalignant question resultswe sharp splenic strikingly suppressive traf3	akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?		backgroundidentification caspases conclusionsour delineate elucidating hodgkin hubs imperative interactome interactors inverted lentiviral lymphomagenesis lymphomas manipulate mark mcc methodswe nhl oncogenes parp1 premalignant question resultswe sharp splenic strikingly suppressive traf3	akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?