ADAT3 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAT3	SORBS3
Description		adenosine deaminase tRNA specific 3	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Catalytic Activity Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	TRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		tRNA modification in the nucleus and cytosol	Smooth Muscle Contraction
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		4 interacting genes: CDA FBLIM1 SORBS3 THRB	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		113179	10174
HPRD ID		14000	11535
Ensembl ID		ENSG00000213638	ENSG00000120896
Uniprot IDs		D6W601 Q96EY9	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Nucleoside Binding Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Thyroid Hormone Receptor Signaling Pathway Retinal Cone Cell Apoptotic Process Female Courtship Behavior Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway UMP Salvage Response To Cycloheximide Pyrimidine-containing Compound Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of Female Receptivity Female Mating Behavior Retinal Cell Apoptotic Process Thyroid Hormone Binding Cell-substrate Junction Type I Pneumocyte Differentiation Cytidine Deaminase Activity UMP Biosynthetic Process Retinal Cone Cell Development Cellular Response To Thyroid Hormone Stimulus Vinculin Binding Filamin Binding Regulation Of Integrin Activation Pyrimidine Nucleobase Metabolic Process Mating Behavior Anchoring Junction Focal Adhesion Detection Of Light Stimulus Involved In Visual Perception Pyrimidine Ribonucleotide Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Response To Thyroid Hormone	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
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