KLHL2 and FRAS1

		KLHL2	FRAS1
Description		kelch like family member 2	Fraser extracellular matrix complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Basement Membrane Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Anatomical Structure Morphogenesis Protein Transport Embryonic Limb Morphogenesis Skin Development Animal Organ Development System Development Roof Of Mouth Development
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Fraser syndrome
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Blond vs. brown/black hair color ( 30531825) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		11275	80144
HPRD ID		09311	06382
Ensembl ID		ENSG00000109466	ENSG00000138759
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q86XX4
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Ubiquitin-like Ligase-substrate Adaptor Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Positive Regulation Of SREBP Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Maturation Regulation Of SREBP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Peroxisome Proliferator Activated Receptor Signaling Pathway
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