FRAS1

Description		Fraser extracellular matrix complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Anatomical Structure Morphogenesis Protein Transport Embryonic Limb Morphogenesis Skin Development Animal Organ Development System Development Roof Of Mouth Development
Pathways
Drugs
Diseases		Fraser syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)
Novel Interacting Genes		4 novel interacting genes: ANTXR2 KLHL2 NAA11 PAQR3
Interacting Genes
Entrez ID		80144
HPRD ID		06382
Ensembl ID		ENSG00000138759
Uniprot IDs		Q86XX4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Ligase-substrate Adaptor Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Positive Regulation Of SREBP Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Maturation Regulation Of SREBP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Peroxisome Proliferator Activated Receptor Signaling Pathway
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