CWC22 and PDAP1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CWC22	PDAP1
Description		CWC22 spliceosome associated protein	PDGFA associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Region Cytosol Plasma Membrane Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome	Signal Transduction
Pathways		mRNA Splicing - Major Pathway	Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 30285260)	Facial emotion recognition (sad faces) ( 28608620) Mean spheric corpuscular volume ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		7 interacting genes: CFTR EIF4A3 EXOSC8 KLHL2 PDAP1 PTPN21 RNF10	9 interacting genes: APP CEBPA CSNK2A1 CWC22 FZD7 PDGFA PDGFB PDGFRB SF1
Entrez ID		57703	11333
HPRD ID		17220	06149
Ensembl ID		ENSG00000163510	ENSG00000106244
Uniprot IDs		Q9HCG8	Q13442
PDB IDs		4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV 6YVH 6ZYM 7A5P 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Macromolecule Catabolic Process Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Nervous System Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Enamel Mineralization Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Translational Elongation RNA Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation RRNA Processing Negative Regulation Of Schwann Cell Proliferation U4 SnRNA 3'-end Processing Amelogenesis Cellular Response To Brain-derived Neurotrophic Factor Stimulus Ribosome-associated Ubiquitin-dependent Protein Catabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential Catabolic Process RRNA Metabolic Process TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance U2-type Catalytic Step 1 Spliceosome	Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Binding Platelet-derived Growth Factor Receptor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Platelet Alpha Granule Lumen Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Autophosphorylation Smooth Muscle Adaptation Positive Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Glomerular Mesangial Cell Proliferation Chemotaxis Golgi Lumen Protein Heterodimerization Activity Regulation Of Protein Autophosphorylation Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Receptor Ligand Activity Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemotaxis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Embryonic Organ Development Response To Platelet-derived Growth Factor
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