TXNDC12 and DPF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TXNDC12	DPF2
Description		thioredoxin domain containing 12	double PHD fingers 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SWI/SNF Complex NBAF Complex
	Molecular Function	Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone H3K14ac Reader Activity Histone H4K16ac Reader Activity
	Biological Process	Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of G0 To G1 Transition Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: CAMLG DPF2 FKBP7 KLHL2 SGTA SGTB UBQLN1 UBQLN2 ZDHHC17	20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655
Entrez ID		51060	5977
HPRD ID		11633	03394
Ensembl ID		ENSG00000117862	ENSG00000133884
Uniprot IDs		O95881	J3KMZ8 Q92785
PDB IDs		1SEN 2K8V	3IUF 5B79 5VDC 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Identical Protein Binding Protein Insertion Into ER Membrane Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Protein Catabolic Process Response To Endoplasmic Reticulum Stress Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Myeloid Progenitor Cell Differentiation Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Store-operated Calcium Channel Activity Protein Insertion Into Membrane Protein Targeting To Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Internalization Autophagosome Assembly Autophagosome Organization Macromolecule Catabolic Process GET Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Protein Catabolic Process Localization Within Membrane Regulation Of Myeloid Progenitor Cell Differentiation Histone H3K14ac Reader Activity BAT3 Complex Binding Proteolysis Negative Regulation Of Clathrin-dependent Endocytosis	NF-kappaB Complex Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interferon-beta Production Structural Constituent Of Chromatin Response To Muramyl Dipeptide Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm
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