PAFAH1B3 and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		PAFAH1B3	SUMO4
Description		platelet activating factor acetylhydrolase 1b catalytic subunit 3	small ubiquitin like modifier 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Membrane	Nucleus SUMO Ligase Complex
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Lipid Metabolic Process Spermatogenesis Nervous System Development Lipid Catabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		COPI-independent Golgi-to-ER retrograde traffic
Drugs		(1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
Diseases
GWAS			Dupuytren's disease ( 28886342)
Interacting Genes		37 interacting genes: BRD7 CCDC90B CHMP7 COPS6 CRMP1 DDX24 ECH1 EEF1A1 ERG28 FXR1 GAPDH GBP2 GDF9 HSPH1 IGSF21 LNX1 LRIF1 MED31 MEI4 NIF3L1 PAFAH1B1 PAFAH1B2 PICK1 PLEKHM1 RBM48 SDCBP2 SETDB1 SUMO4 TERF1 TERF2IP TLE1 TP53 TUBB2A UNC119 XRCC6 ZBTB16 ZHX1	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		5050	387082
HPRD ID		04354	10584
Ensembl ID		ENSG00000079462	ENSG00000177688
Uniprot IDs		A0A024R0L6 Q15102	Q6EEV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Identical Protein Binding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Telomeric DNA Binding Protein Heterodimerization Activity Negative Regulation Of Telomere Maintenance Shelterin Complex Nucleolus Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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