CRADD and SLC35A3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CRADD	SLC35A3
Description		CARD and death domain containing adaptor protein	solute carrier family 35 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding	UDP-galactose Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transporter Activity Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	UDP-N-acetylglucosamine Metabolic Process Transmembrane Transport UDP-galactose Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) Transport of nucleotide sugars
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 33713608 18391951 31217584 28552196 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560 30061609) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Incident chronic kidney disease ( 30955190)
Interacting Genes		22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1	2 interacting genes: CRADD TP63
Entrez ID		8738	23443
HPRD ID		04584	10413
Ensembl ID		ENSG00000169372	ENSG00000117620
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	A0A1W2PQL8 A0A1W2PR66 A0A1W2PRT7 A0A1W2PSD1 Q9Y2D2
PDB IDs		2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Death Receptor Binding Endopeptidase Complex Extrinsic Apoptotic Signaling Pathway Signal Transduction Identical Protein Binding Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Regulation Of Macrophage Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Amyloid Fibril Formation Apoptotic Signaling Pathway Regulation Of Necroptotic Process Integrin Binding Actin Filament Uncapping Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Interleukin-9 Binding Interleukin-9 Receptor Activity Negative Regulation Of Eosinophil Extravasation Cellular Response To Thyrotropin-releasing Hormone Symbiont-containing Vacuole L-xylulose Reductase (NADPH) Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Supramolecular Fiber Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Positive Regulation Of Apoptotic Signaling Pathway Female Genitalia Morphogenesis Positive Regulation Of Somatic Stem Cell Population Maintenance Signal Transduction By P53 Class Mediator Cloacal Septation Ectoderm And Mesoderm Interaction Epidermal Cell Division Apoptotic Signaling Pathway Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Death Domain Binding Endopeptidase Complex Prostatic Bud Formation Regulation Of Apoptotic Signaling Pathway Morphogenesis Of A Polarized Epithelium Regulation Of Mesoderm Development Positive Regulation Of Programmed Cell Death Lateral Sprouting From An Epithelium Positive Regulation Of Apoptotic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Fibroblast Apoptotic Process Genitalia Morphogenesis MDM2/MDM4 Family Protein Binding Regulation Of Somatic Stem Cell Population Maintenance Skin Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Epidermal Cell Differentiation Morphogenesis Of An Epithelial Fold Prostate Gland Development Positive Regulation Of Keratinocyte Proliferation Sympathetic Nervous System Development Cranial Skeletal System Development DNA Damage Response Post-anal Tail Morphogenesis Glandular Epithelial Cell Differentiation Cell Death Regulation Of Fibroblast Apoptotic Process Establishment Of Planar Polarity Apoptotic Process Prostate Gland Epithelium Morphogenesis Programmed Cell Death WW Domain Binding Polarized Epithelial Cell Differentiation Animal Organ Formation Negative Regulation Of Cellular Senescence Morphogenesis Of Embryonic Epithelium Embryonic Hindlimb Morphogenesis Keratinocyte Proliferation
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