CRADD and SLC35A3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRADD	SLC35A3
Gene Name		CASP2 and RIPK1 domain containing adaptor with death domain	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding	Sugar:proton Symporter Activity UDP-N-acetylglucosamine Transmembrane Transporter Activity Protein Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway	UDP-N-acetylglucosamine Metabolic Process Carbohydrate Transport UDP-N-acetylglucosamine Transport Proton Transport Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport
Pathways			Transport of nucleotide sugars Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Height ( 18391951)
Protein-Protein Interactions		18 interactors: APP APPL2 BBS5 C14orf1 CASP2 CASP8 CCSER2 DCXR EEF1A1 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN	2 interactors: CRADD TP63
Entrez ID		8738	23443
HPRD ID		04584	10413
Ensembl ID		ENSG00000169372	ENSG00000117620
Uniprot IDs		F5H7C2 P78560 Q53XL1	Q9BSB7 Q9Y2D2
PDB IDs		2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Execution Phase Of Apoptosis Protein Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of Proteolysis Extrinsic Apoptotic Signaling Pathway Zymogen Activation Programmed Cell Death Cell Death Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Copper Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Sterol Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Endopeptidase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Oligomerization Mating Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Mating Interleukin-9-mediated Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Positive Regulation Of Apoptotic Process Steroid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Programmed Cell Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Ectoderm And Mesoderm Interaction Epidermal Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Cell Cycle Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Apoptotic Signaling Pathway Regulation Of Epidermal Cell Division Regulation Of Endopeptidase Activity Regulation Of Mitotic Cell Cycle Regulation Of Peptidase Activity Female Genitalia Morphogenesis Negative Regulation Of Cell Cycle Cloacal Septation Urinary Bladder Development Regulation Of Cell Cycle Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Proteolysis
Tagcloud ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled sqrdl transcriptomic xenobiotic
Tagcloud (Intersection) ?