CRADD and BBS5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CRADD	BBS5
Gene Name		CASP2 and RIPK1 domain containing adaptor with death domain	Bardet-Biedl syndrome 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Intracellular Cytosol BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Heart Looping Organelle Organization Visual Perception Protein Transport Melanosome Transport Cilium Assembly Motile Cilium Assembly Response To Stimulus
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Height ( 18391951)
Protein-Protein Interactions		18 interactors: APP APPL2 BBS5 C14orf1 CASP2 CASP8 CCSER2 DCXR EEF1A1 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN	2 interactors: CRADD KLC3
Entrez ID		8738	129880
HPRD ID		04584	10353
Ensembl ID		ENSG00000169372	ENSG00000163093
Uniprot IDs		F5H7C2 P78560 Q53XL1	Q8N3I7
PDB IDs		2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Execution Phase Of Apoptosis Protein Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of Proteolysis Extrinsic Apoptotic Signaling Pathway Zymogen Activation Programmed Cell Death Cell Death Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Copper Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Sterol Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Endopeptidase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Oligomerization Mating Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Mating Interleukin-9-mediated Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Positive Regulation Of Apoptotic Process Steroid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Programmed Cell Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Axon Cargo Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Cellular Response To Mechanical Stimulus G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Extrinsic Apoptotic Signaling Pathway Zymogen Activation Signal Transduction By P53 Class Mediator Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Microtubule-based Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endopeptidase Activity Regulation Of Cell Cycle G1/S Phase Transition Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Peptidase Activity DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Protein Processing
Tagcloud ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Difference) ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Intersection) ?