POLB and EP300

Number of citations of the paper that reports this interaction (PMID 12453427)
27

Data Source:
BioGRID (pull down, enzymatic study)

		POLB	EP300
Gene Name		polymerase (DNA directed), beta	E1A binding protein p300
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Spindle Microtubule	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Microtubule Binding Lyase Activity Enzyme Binding Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Androgen Receptor Binding Pre-mRNA Intronic Binding
	Biological Process	DNA-dependent DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Pyrimidine Dimer Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ethanol Neuron Apoptotic Process DNA Biosynthetic Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Somitogenesis Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Internal Protein Amino Acid Acetylation Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Nervous System Development Heart Development Skeletal Muscle Tissue Development Circadian Rhythm Organ Morphogenesis Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Lung Development Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Tubulin Deacetylation Regulation Of Cellular Response To Heat
Pathways		Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt NOTCH2 intracellular domain regulates transcription Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase G2/M Transition HATs acetylate histones RORA activates circadian gene expression HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Cell Cycle, Mitotic RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression Polo-like kinase mediated events
Drugs		Cytarabine 2\'-Deoxyadenosine 5\'-Triphosphate (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Diseases
GWAS			Crohn's disease ( 22936669)
Protein-Protein Interactions		17 interactors: APEX1 EP300 HUWE1 KAT7 NEIL1 PARP1 PCNA PNKP PRKCA RAD1 SRPK2 STUB1 TAF1D TLE1 TPP2 WRN XRCC1	344 interactors: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALX1 APEX1 AR ARNT ARNTL ARSF ASCL1 ASH2L ATF5 ATR BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDKN1A CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CLTC CNOT4 CNTN2 COPS2 COPS6 CREB1 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 E2F5 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO1 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B HAND2 HBP1 HDAC1 HDAC3 HDAC6 HERC1 HIF1A HIPK2 HIST1H1A HIST1H1D HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AB HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCM3AP MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MPG MRE11A MSH6 MSTO1 MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFKB1 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR2F2 NR4A1 NUP98 NUPR1 NUTM1 OLIG2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PROX1 PTMA RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 SATB1 SAV1 SENP3 SEPP1 SERTAD1 SET SETD1A SGCG SIRT1 SIRT2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SRC SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBE2D1 UBE2I UBQLN1 USF2 VPS18 WDR59 WDR82 XRCC6 YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2
Entrez ID		5423	2033
HPRD ID		07517	04078
Ensembl ID		ENSG00000070501	ENSG00000100393
Uniprot IDs		B7Z1W5 P06746	Q09472 Q7Z6C1
PDB IDs		1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO 1ZQP 1ZQQ 1ZQR 1ZQS 1ZQT 2FMP 2FMQ 2FMS 2I9G 2ISO 2ISP 2P66 2PXI 3C2K 3C2L 3C2M 3GDX 3ISB 3ISC 3ISD 3JPN 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT 3LK9 3MBY 3OGU 3RH4 3RH5 3RH6 3RJE 3RJF 3RJG 3RJH 3RJI 3RJJ 3RJK 3TFR 3TFS 4DO9 4DOA 4DOB 4DOC 4F5N 4F5O 4F5P 4F5Q 4F5R 4GXI 4GXJ 4GXK 4JWM 4JWN 4KLD 4KLE 4KLF 4KLG 4KLH 4KLI 4KLJ 4KLL 4KLM 4KLO 4KLQ 4KLS 4KLT 4KLU 4LVS 7ICE 7ICF 7ICG 7ICH 7ICI 7ICJ 7ICK 7ICL 7ICM 7ICN 7ICO 7ICP 7ICQ 7ICR 7ICS 7ICT 7ICU 7ICV 8ICA 8ICB 8ICC 8ICE 8ICF 8ICG 8ICH 8ICI 8ICJ 8ICK 8ICL 8ICM 8ICN 8ICO 8ICP 8ICQ 8ICR 8ICS 8ICT 8ICU 8ICV 8ICW 8ICX 8ICY 8ICZ 9ICA 9ICB 9ICC 9ICE 9ICF 9ICG 9ICH 9ICI 9ICJ 9ICK 9ICL 9ICM 9ICN 9ICO 9ICP 9ICQ 9ICR 9ICS 9ICT 9ICU 9ICV 9ICW 9ICX 9ICY	1L3E 1P4Q 2K8F 3BIY 3I3J 3IO2 3P57 3T92 4BHW
Enriched GO Terms of Interacting Partners?		Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process DNA Replication Chromosome Organization Telomere Maintenance Nucleotide-excision Repair Cellular Metabolic Process DNA-dependent DNA Replication Regulation Of Growth Rate Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process Cellular Response To Stimulus Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Response To Stimulus Telomere Maintenance Via Semi-conservative Replication Metabolic Process Organelle Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Radiation Histone Modification Double-strand Break Repair Positive Regulation Of Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Gene Expression DNA Strand Elongation Negative Regulation Of Biosynthetic Process Aromatic Compound Catabolic Process Protein Polyubiquitination Telomere Maintenance Via Telomere Lengthening Response To Radiation DNA Catabolic Process, Exonucleolytic Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Transcription-coupled Nucleotide-excision Repair	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Response To Organic Substance Cell Differentiation Regulation Of Cell Differentiation Developmental Process Regulation Of Cell Proliferation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Organic Substance System Development Cellular Response To Stress Response To Stress Regulation Of Cellular Process Tissue Development
Tagcloud ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Intersection) ?