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POLB
Gene Name
polymerase (DNA directed), beta
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Microtubule
Spindle Microtubule
Molecular Function
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Microtubule Binding
Lyase Activity
Enzyme Binding
Metal Ion Binding
Biological Process
DNA-dependent DNA Replication
DNA Repair
Base-excision Repair
Base-excision Repair, Gap-filling
Pyrimidine Dimer Repair
Nucleotide-excision Repair, DNA Gap Filling
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ethanol
Neuron Apoptotic Process
DNA Biosynthetic Process
Pathways
Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Removal of DNA patch containing abasic residue
Resolution of AP sites via the single-nucleotide replacement pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
Resolution of Abasic Sites (AP sites)
Drugs
Cytarabine
2\'-Deoxyadenosine 5\'-Triphosphate
(1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Diseases
GWAS
Protein-protein Interactions
17 interactors:
APEX1
EP300
HUWE1
KAT7
NEIL1
PARP1
PCNA
PNKP
PRKCA
RAD1
SRPK2
STUB1
TAF1D
TLE1
TPP2
WRN
XRCC1
Entrez ID
5423
HPRD ID
07517
Ensembl ID
ENSG00000070501
Uniprot IDs
B7Z1W5
P06746
PDB IDs
1BPX
1BPY
1BPZ
1MQ2
1MQ3
1TV9
1TVA
1ZJM
1ZJN
1ZQA
1ZQB
1ZQC
1ZQD
1ZQE
1ZQF
1ZQG
1ZQH
1ZQI
1ZQJ
1ZQK
1ZQL
1ZQM
1ZQN
1ZQO
1ZQP
1ZQQ
1ZQR
1ZQS
1ZQT
2FMP
2FMQ
2FMS
2I9G
2ISO
2ISP
2P66
2PXI
3C2K
3C2L
3C2M
3GDX
3ISB
3ISC
3ISD
3JPN
3JPO
3JPP
3JPQ
3JPR
3JPS
3JPT
3LK9
3MBY
3OGU
3RH4
3RH5
3RH6
3RJE
3RJF
3RJG
3RJH
3RJI
3RJJ
3RJK
3TFR
3TFS
4DO9
4DOA
4DOB
4DOC
4F5N
4F5O
4F5P
4F5Q
4F5R
4GXI
4GXJ
4GXK
4JWM
4JWN
4KLD
4KLE
4KLF
4KLG
4KLH
4KLI
4KLJ
4KLL
4KLM
4KLO
4KLQ
4KLS
4KLT
4KLU
4LVS
7ICE
7ICF
7ICG
7ICH
7ICI
7ICJ
7ICK
7ICL
7ICM
7ICN
7ICO
7ICP
7ICQ
7ICR
7ICS
7ICT
7ICU
7ICV
8ICA
8ICB
8ICC
8ICE
8ICF
8ICG
8ICH
8ICI
8ICJ
8ICK
8ICL
8ICM
8ICN
8ICO
8ICP
8ICQ
8ICR
8ICS
8ICT
8ICU
8ICV
8ICW
8ICX
8ICY
8ICZ
9ICA
9ICB
9ICC
9ICE
9ICF
9ICG
9ICH
9ICI
9ICJ
9ICK
9ICL
9ICM
9ICN
9ICO
9ICP
9ICQ
9ICR
9ICS
9ICT
9ICU
9ICV
9ICW
9ICX
9ICY
Enriched GO Terms of Interacting Partners
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Base-excision Repair
Cellular Response To DNA Damage Stimulus
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Stress
Nitrogen Compound Metabolic Process
DNA Replication
Chromosome Organization
Telomere Maintenance
Nucleotide-excision Repair
Cellular Metabolic Process
DNA-dependent DNA Replication
Regulation Of Growth Rate
Nucleic Acid Phosphodiester Bond Hydrolysis
DNA Catabolic Process
Cellular Response To Stimulus
Response To Oxidative Stress
DNA Damage Response, Detection Of DNA Damage
Cellular Macromolecule Catabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleotide-excision Repair, DNA Gap Filling
Response To Stimulus
Telomere Maintenance Via Semi-conservative Replication
Metabolic Process
Organelle Organization
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Cellular Response To Radiation
Histone Modification
Double-strand Break Repair
Positive Regulation Of Metabolic Process
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
Gene Expression
DNA Strand Elongation
Negative Regulation Of Biosynthetic Process
Aromatic Compound Catabolic Process
Protein Polyubiquitination
Telomere Maintenance Via Telomere Lengthening
Response To Radiation
DNA Catabolic Process, Exonucleolytic
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Tagcloud
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accessible
applicable
cancerous
chosen
constitute
crc
csnk1e
ctnnb1
hct
ihc
integrated
isogenic
kill
leave
lethality
msh2
pairs
ranked
rb1
rko
rnai
sl
synergistically
therapeutics
top
tp53
uncovering
verified
wnt5a