POLB and NEIL1

Number of citations of the paper that reports this interaction (PMID 15260972)
132

Data Source:
BioGRID (far western blotting)

		POLB	NEIL1
Gene Name		polymerase (DNA directed), beta	nei endonuclease VIII-like 1 (E. coli)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Spindle Microtubule	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Microtubule Binding Lyase Activity Enzyme Binding Metal Ion Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity
	Biological Process	DNA-dependent DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Pyrimidine Dimer Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ethanol Neuron Apoptotic Process DNA Biosynthetic Process	DNA Catabolic Process, Endonucleolytic Base-excision Repair Nucleotide-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity
Pathways		Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs		Cytarabine 2\'-Deoxyadenosine 5\'-Triphosphate (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APEX1 EP300 HUWE1 KAT7 NEIL1 PARP1 PCNA PNKP PRKCA RAD1 SRPK2 STUB1 TAF1D TLE1 TPP2 WRN XRCC1	4 interactors: APP LIG3 POLB XRCC1
Entrez ID		5423	79661
HPRD ID		07517	12314
Ensembl ID		ENSG00000070501	ENSG00000140398
Uniprot IDs		B7Z1W5 P06746	Q96FI4
PDB IDs		1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO 1ZQP 1ZQQ 1ZQR 1ZQS 1ZQT 2FMP 2FMQ 2FMS 2I9G 2ISO 2ISP 2P66 2PXI 3C2K 3C2L 3C2M 3GDX 3ISB 3ISC 3ISD 3JPN 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT 3LK9 3MBY 3OGU 3RH4 3RH5 3RH6 3RJE 3RJF 3RJG 3RJH 3RJI 3RJJ 3RJK 3TFR 3TFS 4DO9 4DOA 4DOB 4DOC 4F5N 4F5O 4F5P 4F5Q 4F5R 4GXI 4GXJ 4GXK 4JWM 4JWN 4KLD 4KLE 4KLF 4KLG 4KLH 4KLI 4KLJ 4KLL 4KLM 4KLO 4KLQ 4KLS 4KLT 4KLU 4LVS 7ICE 7ICF 7ICG 7ICH 7ICI 7ICJ 7ICK 7ICL 7ICM 7ICN 7ICO 7ICP 7ICQ 7ICR 7ICS 7ICT 7ICU 7ICV 8ICA 8ICB 8ICC 8ICE 8ICF 8ICG 8ICH 8ICI 8ICJ 8ICK 8ICL 8ICM 8ICN 8ICO 8ICP 8ICQ 8ICR 8ICS 8ICT 8ICU 8ICV 8ICW 8ICX 8ICY 8ICZ 9ICA 9ICB 9ICC 9ICE 9ICF 9ICG 9ICH 9ICI 9ICJ 9ICK 9ICL 9ICM 9ICN 9ICO 9ICP 9ICQ 9ICR 9ICS 9ICT 9ICU 9ICV 9ICW 9ICX 9ICY	1TDH
Enriched GO Terms of Interacting Partners?		Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process DNA Replication Chromosome Organization Telomere Maintenance Nucleotide-excision Repair Cellular Metabolic Process DNA-dependent DNA Replication Regulation Of Growth Rate Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process Cellular Response To Stimulus Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Response To Stimulus Telomere Maintenance Via Semi-conservative Replication Metabolic Process Organelle Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Radiation Histone Modification Double-strand Break Repair Positive Regulation Of Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Gene Expression DNA Strand Elongation Negative Regulation Of Biosynthetic Process Aromatic Compound Catabolic Process Protein Polyubiquitination Telomere Maintenance Via Telomere Lengthening Response To Radiation DNA Catabolic Process, Exonucleolytic Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Transcription-coupled Nucleotide-excision Repair	Base-excision Repair Neuron Apoptotic Process Neuron Death DNA Repair DNA-dependent DNA Replication DNA Biosynthetic Process Cellular Response To DNA Damage Stimulus Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Base-excision Repair, DNA Ligation Otolith Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, Gap-filling DNA Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Cellular Response To Stress Otolith Development Axon Choice Point Recognition Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair Nucleobase-containing Compound Metabolic Process Neuron Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Dimer Repair DNA Ligation Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Single Strand Break Repair Cellular Copper Ion Homeostasis Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity DNA Strand Elongation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation
Tagcloud ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt
Tagcloud (Difference) ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt
Tagcloud (Intersection) ?