POLB and STUB1

Number of citations of the paper that reports this interaction (PMID 19713937)
27

Data Source:
BioGRID (enzymatic study)

		POLB	STUB1
Gene Name		polymerase (DNA directed), beta	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Spindle Microtubule	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Microtubule Binding Lyase Activity Enzyme Binding Metal Ion Binding	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA-dependent DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Pyrimidine Dimer Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ethanol Neuron Apoptotic Process DNA Biosynthetic Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs		Cytarabine 2\'-Deoxyadenosine 5\'-Triphosphate (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APEX1 EP300 HUWE1 KAT7 NEIL1 PARP1 PCNA PNKP PRKCA RAD1 SRPK2 STUB1 TAF1D TLE1 TPP2 WRN XRCC1	92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP
Entrez ID		5423	10273
HPRD ID		07517	06232
Ensembl ID		ENSG00000070501	ENSG00000103266
Uniprot IDs		B7Z1W5 P06746	Q9UNE7
PDB IDs		1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO 1ZQP 1ZQQ 1ZQR 1ZQS 1ZQT 2FMP 2FMQ 2FMS 2I9G 2ISO 2ISP 2P66 2PXI 3C2K 3C2L 3C2M 3GDX 3ISB 3ISC 3ISD 3JPN 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT 3LK9 3MBY 3OGU 3RH4 3RH5 3RH6 3RJE 3RJF 3RJG 3RJH 3RJI 3RJJ 3RJK 3TFR 3TFS 4DO9 4DOA 4DOB 4DOC 4F5N 4F5O 4F5P 4F5Q 4F5R 4GXI 4GXJ 4GXK 4JWM 4JWN 4KLD 4KLE 4KLF 4KLG 4KLH 4KLI 4KLJ 4KLL 4KLM 4KLO 4KLQ 4KLS 4KLT 4KLU 4LVS 7ICE 7ICF 7ICG 7ICH 7ICI 7ICJ 7ICK 7ICL 7ICM 7ICN 7ICO 7ICP 7ICQ 7ICR 7ICS 7ICT 7ICU 7ICV 8ICA 8ICB 8ICC 8ICE 8ICF 8ICG 8ICH 8ICI 8ICJ 8ICK 8ICL 8ICM 8ICN 8ICO 8ICP 8ICQ 8ICR 8ICS 8ICT 8ICU 8ICV 8ICW 8ICX 8ICY 8ICZ 9ICA 9ICB 9ICC 9ICE 9ICF 9ICG 9ICH 9ICI 9ICJ 9ICK 9ICL 9ICM 9ICN 9ICO 9ICP 9ICQ 9ICR 9ICS 9ICT 9ICU 9ICV 9ICW 9ICX 9ICY
Enriched GO Terms of Interacting Partners?		Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process DNA Replication Chromosome Organization Telomere Maintenance Nucleotide-excision Repair Cellular Metabolic Process DNA-dependent DNA Replication Regulation Of Growth Rate Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process Cellular Response To Stimulus Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Response To Stimulus Telomere Maintenance Via Semi-conservative Replication Metabolic Process Organelle Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Radiation Histone Modification Double-strand Break Repair Positive Regulation Of Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Gene Expression DNA Strand Elongation Negative Regulation Of Biosynthetic Process Aromatic Compound Catabolic Process Protein Polyubiquitination Telomere Maintenance Via Telomere Lengthening Response To Radiation DNA Catabolic Process, Exonucleolytic Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Transcription-coupled Nucleotide-excision Repair	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process
Tagcloud ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Difference) ?		accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Intersection) ?