ZWINT and NDC80

Number of citations of the paper that reports this interaction (PMID 15824131)
62

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		ZWINT	NDC80
Gene Name		ZW10 interacting kinetochore protein	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Cytoplasm Cytosol Dendrite	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Protein N-terminus Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Cell Division Establishment Of Localization In Cell	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		9 interactors: APP CLU DSN1 LIG4 MAFB MIS12 NDC80 PHAX ZW10	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		11130	10403
HPRD ID		18366	06277
Ensembl ID		ENSG00000122952	ENSG00000080986
Uniprot IDs		O95229	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Division Chromosome Segregation Mitotic Nuclear Division Cell Cycle Mitotic Cell Cycle Process Cell Activation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Spindle Localization Neuron Apoptotic Process Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Cellular Component Assembly Platelet Degranulation Organelle Organization Chromosome Organization Cell Cycle Process Mitotic Sister Chromatid Segregation Rhombomere 6 Development Positive Regulation Of Tau-protein Kinase Activity DNA Ligation Involved In DNA Recombination Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Establishment Of Localization In Cell Sister Chromatid Segregation Leukocyte Activation SnRNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Positive Regulation Of Neurofibrillary Tangle Assembly Establishment Of Cell Polarity Cellular Localization Brain Segmentation Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Central Nervous System Myelin Maintenance Rhombomere 5 Development T Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Tau-protein Kinase Activity Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		androgens ar arbss castration chip chromatin combining crpc crpcs deep emergence endonuclease explaining fen1 flap knock lncap overexpressing p45 pc prostatectomy reactivated sensitizes seq skp2 snai2 sublines took xenografts	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		androgens ar arbss castration chip chromatin combining crpc crpcs deep emergence endonuclease explaining fen1 flap knock lncap overexpressing p45 pc prostatectomy reactivated sensitizes seq skp2 snai2 sublines took xenografts	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?