ZWINT and FAM90A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZWINT	FAM90A1
Description		ZW10 interacting kinetochore protein	family with sequence similarity 90 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Dendrite Knl1/Spc105 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Homologous Chromosome Orientation In Meiotic Metaphase I Cell Division Establishment Of Localization In Cell Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)	Gut microbiota (functional units) ( 27694959)
Interacting Genes		17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10	162 interacting genes: ABI2 ACTN3 AKAP9 AMOTL2 ANKRD23 ANKRD29 AP2M1 APP ARHGEF9 ARRDC3 BANP BCAR1 BEGAIN BLZF1 CADPS CALCOCO2 CARD9 CCDC13 CCDC57 CCN3 CCNC CCNL2 CDR2 CEP55 CEP70 CEP72 CEP76 CHRDL2 COG6 CYSRT1 DTX3 DVL2 DVL3 EFEMP2 ENKD1 EXOSC8 FAM228A FHL3 FLACC1 FLOT1 FOSB FSD2 FXR1 FXR2 FYN GABPB1 GCSAML GNPTAB GOLGA2 GOPC GPRASP3 GPSM1 GRIPAP1 HAND2 HMBOX1 HOMER3 HOMEZ HOOK2 HSF2BP ISY1 KANK2 KASH5 KIFC3 KLHL12 KPNA6 KRT31 KRT34 KRT38 KRT40 KRTAP1-1 KRTAP10-8 LDOC1 LHX6 LIMS1 LMO2 LNX1 LRP2BP LRRK2 LZTS1 LZTS2 MAD1L1 MDFI MEIS3 MID2 MIPOL1 MLH1 MORN3 MSS51 MTUS2 MYOG NBPF19 NDUFB7 NOTCH2NLA NUDT21 OVOL1 PBX1 PBX2 PDLIM7 PFDN5 PICK1 PIH1D1 PLAGL2 POF1B PPARA PPP1R13B PRDM6 PRKAR1B PRR23B PSME3 PSTPIP1 RAB11FIP2 RABEP1 RBM48 REL RHOH RINT1 ROPN1 RPRD1A SH2B2 SIAH1 SMAD3 SMARCB1 SNW1 SPRED1 SRPK2 STAC3 STMN2 STX11 TAX1BP1 TEPSIN TFIP11 TLE5 TMCC2 TRAF2 TRAF4 TRIB3 TRIM23 TRIM27 TRIM42 TRIM54 TRIM55 TRIM69 TRIM9 TRIML2 VRTN VWC2 ZBTB14 ZBTB16 ZBTB7B ZBTB8A ZC2HC1C ZMYND12 ZNF143 ZNF212 ZNF343 ZNF526 ZNF581 ZNF655 ZNF688 ZNF76 ZRANB1 ZWINT
Entrez ID		11130	55138
HPRD ID		18366	07672
Ensembl ID		ENSG00000122952	ENSG00000171847
Uniprot IDs		O95229	Q86YD7
PDB IDs		8PPR
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Positive Regulation Of Amyloid Fibril Formation Cell Division Mitotic Sister Chromatid Segregation Chromosome Segregation Sister Chromatid Segregation Skeletal Muscle Satellite Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore MIS12/MIND Type Complex Chromosome, Centromeric Region Nuclear Chromosome Segregation Kinetochore Organelle Organization Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell Intracellular Transport Segment Specification Kinetochore Organization Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Chromosome Organization Cellular Localization Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Protein Transport Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Spindle Pole Mitotic Cell Cycle Positive Regulation Of Endocytosis Establishment Of Mitotic Spindle Orientation Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Developmental Process Positive Regulation Of Nitric Oxide Metabolic Process Establishment Of Mitotic Spindle Localization Negative Regulation Of Mitotic Nuclear Division Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Establishment Of Integrated Proviral Latency T Cell Differentiation In Thymus Establishment Of Spindle Orientation	Protein Binding Identical Protein Binding Zinc Ion Binding Cytoplasm Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Organelle Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction TORC1 Complex Assembly Cytoskeleton Signaling Adaptor Activity Protein Homodimerization Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Ubiquitination Keratin Filament Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding
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