ZWINT and PHAX

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ZWINT	PHAX
Description		ZW10 interacting kinetochore protein	phosphorylated adaptor for RNA export
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Dendrite Knl1/Spc105 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Neuronal Cell Body Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Protein Binding Toxic Substance Binding MRNA Cap Binding Complex Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Homologous Chromosome Orientation In Meiotic Metaphase I Cell Division Establishment Of Localization In Cell Regulation Of Meiosis I Spindle Assembly Checkpoint	SnRNA Export From Nucleus Protein Transport RNA Stabilization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	snRNP Assembly RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)	Bipolar disorder ( 34099189) Colorectal cancer ( 30529582)
Interacting Genes		17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10	16 interacting genes: ASPSCR1 CDC42 GADD45G GRB7 MKNK1 NSFL1C OGT PDPK1 RAD23A RPS6KA1 TNFSF11 TULP3 UBXN2A VAV1 XPO1 ZWINT
Entrez ID		11130	51808
HPRD ID		18366	15122
Ensembl ID		ENSG00000122952	ENSG00000164902
Uniprot IDs		O95229	Q9H814
PDB IDs		8PPR	2XC7 8PNT
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Positive Regulation Of Amyloid Fibril Formation Cell Division Mitotic Sister Chromatid Segregation Chromosome Segregation Sister Chromatid Segregation Skeletal Muscle Satellite Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore MIS12/MIND Type Complex Chromosome, Centromeric Region Nuclear Chromosome Segregation Kinetochore Organelle Organization Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell Intracellular Transport Segment Specification Kinetochore Organization Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Chromosome Organization Cellular Localization Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Protein Transport Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Spindle Pole Mitotic Cell Cycle Positive Regulation Of Endocytosis Establishment Of Mitotic Spindle Orientation Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Developmental Process Positive Regulation Of Nitric Oxide Metabolic Process Establishment Of Mitotic Spindle Localization Negative Regulation Of Mitotic Nuclear Division Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Establishment Of Integrated Proviral Latency T Cell Differentiation In Thymus Establishment Of Spindle Orientation	Cytoplasm Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Organization Intracellular Signal Transduction Regulation Of Signal Transduction Nuclear Membrane Reassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Activation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling 3-phosphoinositide-dependent Protein Kinase Activity T Cell Costimulation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Organelle Localization Nuclear Membrane Organization Cell Projection Positive Regulation Of Cell Adhesion Leukocyte Migration GBD Domain Binding Storage Vacuole Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Bronchus Morphogenesis Cellular Response To Triglyceride Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I VCP-NSFL1C Complex Membrane Assembly Negative Regulation Of Protein Localization To Centrosome
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