ZWINT and MIS12

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vivo, in vitro)

		ZWINT	MIS12
Gene Name		ZW10 interacting kinetochore protein	MIS12 kinetochore complex component
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Cytoplasm Cytosol Dendrite	MIS12/MIND Type Complex Nucleus Cytosol
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Cell Division Establishment Of Localization In Cell	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division Kinetochore Assembly
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		9 interactors: APP CLU DSN1 LIG4 MAFB MIS12 NDC80 PHAX ZW10	10 interactors: CASC5 CBX3 CBX5 DSN1 HSP90AA1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		11130	79003
HPRD ID		18366	12379
Ensembl ID		ENSG00000122952	ENSG00000167842
Uniprot IDs		O95229	A8K1M4 Q9H081
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Division Chromosome Segregation Mitotic Nuclear Division Cell Cycle Mitotic Cell Cycle Process Cell Activation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Spindle Localization Neuron Apoptotic Process Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Cellular Component Assembly Platelet Degranulation Organelle Organization Chromosome Organization Cell Cycle Process Mitotic Sister Chromatid Segregation Rhombomere 6 Development Positive Regulation Of Tau-protein Kinase Activity DNA Ligation Involved In DNA Recombination Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Establishment Of Localization In Cell Sister Chromatid Segregation Leukocyte Activation SnRNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Positive Regulation Of Neurofibrillary Tangle Assembly Establishment Of Cell Polarity Cellular Localization Brain Segmentation Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Central Nervous System Myelin Maintenance Rhombomere 5 Development T Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Tau-protein Kinase Activity Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation	Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Cell Cycle Cell Division Organelle Organization Attachment Of Spindle Microtubules To Kinetochore Chromosome Organization Microtubule Anchoring Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Maintenance Of Protein Location In Cell Protein Import Into Mitochondrial Outer Membrane Chromatin Modification Maintenance Of Protein Location Maintenance Of Location In Cell Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Chromatin Organization Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Histone H4-K5 Acetylation Histone H4-K8 Acetylation Chaperone-mediated Protein Complex Assembly Histone H4-K16 Acetylation Acrosome Assembly
Tagcloud ?		androgens ar arbss castration chip chromatin combining crpc crpcs deep emergence endonuclease explaining fen1 flap knock lncap overexpressing p45 pc prostatectomy reactivated sensitizes seq skp2 snai2 sublines took xenografts	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		androgens ar arbss castration chip chromatin combining crpc crpcs deep emergence endonuclease explaining fen1 flap knock lncap overexpressing p45 pc prostatectomy reactivated sensitizes seq skp2 snai2 sublines took xenografts	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?